Glyburide Pregnancy and Breastfeeding Warnings

Glyburide is also known as: DiaBeta, Glycron, Glynase, Glynase PresTab, Micronase

Glyburide Pregnancy Warnings

Maternal to fetal transfer of the second generation sulfonylureas (i.e. glyburide, glipizide) appears to be significantly lower than that of the first generation sulfonylureas. This data suggests that reduced or insignificant fetal exposure may occur with maternal administration of the second generation agents. Additional studies are needed to fully assess the safety of these agents for use during pregnancy.

Glyburide has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of fetal toxicity. Other sulfonylureas have been associated with an increased teratogenic risk in animal studies. There are no controlled data in human pregnancy. The use of oral sulfonylureas during pregnancy has been reported to result in neonatal hypoglycemia. Insulin remains the mainstay of therapy for gestational diabetes due to the close glucose control it affords. The manufacturer states that glyburide should not be used during pregnancy. Glyburide is generally considered contraindicated during pregnancy and is only recommend for use during pregnancy when there are no alternatives and benefit outweighs risk.

Glyburide Breastfeeding Warnings

There are no data on the excretion of glyburide into human milk. Other sulfonylureas are excreted into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See Also...

• Glyburide use while Breastfeeding (in more detail)
• Glyburide Consumer Information
• Pregnancy Support Group
• FDA Pregnancy Categories
• Medicine use during Pregnancy
• Medicine use while Breastfeeding
• Safe Medications during Breastfeeding

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This drug information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.