Glyburide Pregnancy and Breastfeeding Warnings
Glyburide Pregnancy Warnings
Maternal to fetal transfer of the second generation sulfonylureas (i.e. glyburide, glipizide) appears to be significantly lower than that of the first generation sulfonylureas. This data suggests that reduced or insignificant fetal exposure may occur with maternal administration of the second generation agents. Additional studies are needed to fully assess the safety of these agents for use during pregnancy.
Glyburide has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of fetal toxicity. Other sulfonylureas have been associated with an increased teratogenic risk in animal studies. There are no controlled data in human pregnancy. Glyburide should be used during pregnancy when the benefit outweighs the risk. Insulin remains the mainstay of therapy for gestational diabetes due to the close glucose control it affords. The use of oral sulfonylureas during pregnancy has been reported to result in neonatal hypoglycemia. If glyburide is used during pregnancy, it should be discontinued at least 2 weeks before the expected delivery date.
Glyburide Breastfeeding Warnings
There are no data on the excretion of glyburide into human milk. Other sulfonylureas are excreted into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
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