Glyburide Pregnancy and Breast Feeding Warnings

Glyburide is also known as: DiaBeta, Glycron, Glynase, Glynase PresTab, Micronase

Overview

If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Glyburide while you are pregnant. If you take Glyburide during pregnancy, do not take it within 2 weeks of the expected delivery date without first checking with your doctor. It is not known if Glyburide is found in breast milk. Do not breast-feed while taking Glyburide .

Glyburide Pregnancy Warnings

Glyburide has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of fetal toxicity. Other sulfonylureas have been associated with an increased teratogenic risk in animal studies. There are no controlled data in human pregnancy. The use of oral sulfonylureas during pregnancy has been reported to result in neonatal hypoglycemia. Insulin remains the mainstay of therapy for gestational diabetes due to the close glucose control it affords. The manufacturer states that glyburide should not be used during pregnancy. Glyburide is generally considered contraindicated during pregnancy and is only recommend for use during pregnancy when there are no alternatives and benefit outweighs risk.

Maternal to fetal transfer of the second generation sulfonylureas (i.e. glyburide, glipizide) appears to be significantly lower than that of the first generation sulfonylureas. This data suggests that reduced or insignificant fetal exposure may occur with maternal administration of the second generation agents. Additional studies are needed to fully assess the safety of these agents for use during pregnancy.

Glyburide Lactation Warnings

There are no data on the excretion of glyburide into human milk. Other sulfonylureas are excreted into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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