Glyburide use while Breastfeeding
Drugs containing Glyburide: Glucovance, DiaBeta, Micronase, Glynase, Glynase PresTab, Glycron
Glyburide Levels and Effects while Breastfeeding
Summary of Use during Lactation
Limited data indicate that the levels of glyburide in milk are negligible. Monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]
Drug Levels
Maternal Levels. Eight women who had recently delivered were given a single dose of glyburide 5 mg (n = 6) or 10 mg (n = 2) orally. Glyburide was undetectable (<5 mcg/L) in milk at 2, 4, 6 and 8 hours after the dose. The authors estimated that the maximum dosages that a fully breastfed infant would receive with the 5 and 10 mg doses are <1.5% and <0.7% of the maternal weight-adjusted dosage, respectively.[3][4]
In a separate study reported in the same paper, 3 women who had delivered via cesarean section and were receiving glyburide 5 mg daily in the immediate postoperative period had milk glyburide levels measured. Trough glyburide milk levels were undetectable (<80 mcg/L).[3]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
The blood glucose level was normal in one breastfed infant whose mothers was taking oral glyburide 5 mg daily.[3]
Possible Effects on Lactation
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
Acarbose, Chlorpropamide, Insulin, Metformin, Tolbutamide
References
3. Everett JA. Use of oral antidiabetic agents during breastfeeding. J Hum Lact. 1997;13:319-21. PMID: 9429368
4. Berlin CM, Briggs GG. Drugs and chemicals in human milk. Semin Fetal Neonatal Med. 2005;10:149-59. PMID: 15701580
1. Feig DS, Briggs GG, Kraemer JM et al. Transfer of glyburide and glipizide into breast milk. Diabetes Care. 2005;28:1851-5. PMID: 16043722
2. Feig DS, Kraemer JM, Moskovitz DN et al. The transfer of glyburide into breast milk. Clin Pharmacol Ther. 2004;75(2):P24. Abstract.
Glyburide Identification
Substance Name
CAS Registry Number
10238-21-8
Drug Class
- Hypoglycemic Agents
- Sulfonylurea Compounds
Administrative Information
LactMed Record Number
128
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
2010-09-02
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
See Also...
- Glyburide use during Pregnancy
- Glyburide Consumer Information
- Breastfeeding Support Group
- Safe Medications during Breastfeeding
- Medicine use while Breastfeeding
- Medicine use during Pregnancy
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