Nabilone Dosage

This dosage information may not include all the information needed to use Nabilone safely and effectively. See additional information for Nabilone.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Nausea/Vomiting - Chemotherapy Induced

Initial dosage: 1 mg or 2 mg orally twice daily 1 to 3 hours before the chemotherapeutic agent is administered. A dose of 1 mg to 2 mg by mouth the night before chemotherapy may be useful.

Nabilone may be administered two to three times daily during the entire course of each cycle of chemotherapy and, if needed, for 48 hours after the last dose of each cycle of chemotherapy.

The maximum recommended daily dose is 6 mg given in divided doses three times daily.

Usual Pediatric Dose for Nausea/Vomiting - Chemotherapy Induced

Safety and effectiveness have not been established in patients younger than 18 years of age. Caution is recommended in prescribing nabilone to children because of psychoactive effects.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Nabilone should not be taken with alcohol, sedatives, hypnotics, or other psychoactive substances because these substances can potentiate the central nervous system effects of nabilone.

The effects of nabilone may persist for a variable and unpredictable period of time following its oral use. Adverse psychiatric reactions can persist for 48 to 72 hours following cessation of therapy.

Nabilone has the potential to affect the CNS, which might manifest itself as dizziness, drowsiness, euphoria "high", ataxia, anxiety, hallucinations, disorientation, depression, and psychosis.

Because of individual variation in response and tolerance to the effects of nabilone, patients should remain under supervision of a responsible adult especially during initial administration and during dose adjustments.

Patients receiving therapy with nabilone should be specifically warned not to drive, operate machinery, or engage in any hazardous activity while receiving nabilone.

Because of the potential for side effects such as orthostatic hypotension, hypotension, hypertension, syncope, or tachycardia, caution is recommended if nabilone is to be used in patients with cardiac disorders.

The effects of QT prolongation potential by nabilone have not been established.

Because nabilone may exacerbate mania, depression, or schizophrenia, both caution and psychiatric monitoring are recommended if nabilone is to be used in patients with a history of these illnesses.

Caution is also recommended if nabilone is to be used in patients with a history of substance abuse including alcohol abuse or dependence and marijuana use, since nabilone contains a similar active compound to marijuana.

The safety aspects of the effects of renal and hepatic impairment have not been investigated.

Nabilone should be used with caution in elderly patients aged 65 and over because they are generally more sensitive to the psychoactive effects of drugs and nabilone can cause postural hypotension and elevate supine and standing heart rates.

Dialysis

Data not available

Other Comments

Nabilone can be given without regard to meals.

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