Keppra-XR Dosage

Generic name: levetiracetam
Dosage form: tablet, film coated, extended release

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KEPPRA XR is administered once daily.

Treatment should be initiated with a dose of 1000 mg once daily. The once daily dosage may be adjusted in increments of 1000 mg every 2 weeks to a maximum recommended once daily dose of 3000 mg.

Adult Patients with Impaired Renal Function

KEPPRA XR dosing must be individualized according to the patient's renal function status. Recommended doses and adjustment for dose for adults are shown in Table 1. In order to calculate the dose recommended for patients with renal impairment, creatinine clearance adjusted for body surface area must be calculated. To do this, an estimate of the patient's creatinine clearance (CLcr) in mL/min must first be calculated using the following formula:

CLcr= [140-age (years)] × weight (kg) (× 0.85 for female patients)
72 × serum creatinine (mg/dL)    

Then CLcr is adjusted for body surface area (BSA) as follows:

CLcr (mL/min/1.73m2)= CLcr (mL/min) × 1.73
BSA subject (m2)    
Table 1: Dosing Adjustment Regimen For Adult Patients With Impaired Renal Function
Group Creatinine
Clearance
(mL/min/1.73m2)
Dosage
(mg)
Frequency
Normal > 80 1000 to 3000 Every 24 hours
Mild 50 – 80 1000 to 2000 Every 24 hours
Moderate 30 – 50 500 to 1500 Every 24 hours
Severe < 30 500 to 1000 Every 24 hours
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