Keppra-XR Dosage
Generic name: levetiracetam
Dosage form: tablet, film coated, extended release
See also:
This dosage information does not include all the information needed to use Keppra-XR safely and effectively. See full prescribing information for Keppra-XR.
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Treatment should be initiated with a dose of 1000 mg once daily. The daily dosage may be adjusted in increments of 1000 mg every 2 weeks to a maximum recommended daily dose of 3000 mg.
Adult Patients With Impaired Renal Function
KEPPRA XR dosing must be individualized according to the patient's renal function status. Recommended doses and adjustment for dose for adults are shown in Table 1. To use this dosing table, an estimate of the patient's creatinine clearance (CLcr) in mL/min is needed. CLcr in mL/min may be estimated from serum creatinine (mg/dL) determination using the following formula:
[140-age (years)] x weight (kg)
CLcr = ---------------------------------------------- x 1 0.85
72 x serum creatinine (mg/dL)
1. For female patients
Then CLcr is adjusted for body surface area (BSA) as follows:
CLcr (mL/min)
CLcr (mL/min/1.73m2) = ----------------------------- x 1.73
BSA subject (m2)
| Group | Creatinine Clearance (mL/min/1.73m2) |
Dosage (mg) |
Frequency |
|---|---|---|---|
| Normal | > 80 | 1000 to 3000 | Every 24 h |
| Mild | 50 – 80 | 1000 to 2000 | Every 24 h |
| Moderate | 30 – 50 | 500 to 1500 | Every 24 h |
| Severe | < 30 | 500 to 1000 | Every 24 h |
