Generic Name: divalproex sodium (dye val PRO ex)
Brand Names: Depakote, Depakote ER, Depakote Sprinkles
What is Depakote?
Depakote (divalproex sodium) affects chemicals in the body that may be involved in causing seizures.
Depakote is used to treat various types of seizure disorders. It is sometimes used together with other seizure medications.
Depakote may also be used for purposes not listed in this medication guide.
Important information about Depakote
Depakote may cause harm to an unborn baby, but having a seizure during pregnancy could harm both the mother and the baby. Tell your doctor right away if you become pregnant while taking Depakote for seizures. Do not start or stop taking Depakote during pregnancy without your doctor's advice.
Seek emergency medical attention if the person taking this medicine has nausea, vomiting, upper stomach pain, or loss of appetite, low fever, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). These symptoms may be early signs of liver damage or pancreatitis. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
Before taking Depakote
In rare cases, Depakote has caused life-threatening liver failure, especially in children younger than 2 years old. Children of this age may be at even greater risk for liver problems if they use more than one seizure medication, if they have a metabolic disorder, or if they have a brain disease causing mental impairment (such as Creutzfeldt-Jacob disease, Huntington disease, multiple sclerosis, or a brain injury or infection). Depakote has also caused rare cases of life-threatening pancreatitis (inflammation of the pancreas). Pancreatitis can come on suddenly and symptoms may start even after you have been taking Depakote for several years. You should not take Depakote if you are allergic to divalproex sodium, or if you have liver disease or a urea cycle disorder.
To make sure you can safely take Depakote, tell your doctor if you have any of these other conditions:
a bleeding or blood clotting disorder;
a history of head injury, brain disorder, or coma;
a family history of a urea cycle disorder or infant deaths with unknown cause; or
HIV or CMV (cytomegalovirus) infection.
You may have thoughts about suicide while taking Depakote. Tell your doctor if you have new or worsening depression or suicidal thoughts during the first several months of treatment, or whenever your dose is changed.
Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.
FDA pregnancy category D. Depakote can cause birth defects. Do not start taking Depakote without telling your doctor if you are pregnant or planning to become pregnant. Use effective birth control while you are taking this medicine.
See also: Depakote pregnancy and breastfeeding warnings (in more detail)
Depakote may also affect cognitive development in children born to mothers who take this medication during pregnancy. Studies have shown that these children may score lower on cognitive tests (reasoning, intelligence, and problem-solving) than children whose mothers took other seizure medications during pregnancy.
Although Depakote may harm an unborn baby, having a seizure during pregnancy could harm both mother and baby. If you become pregnant while taking Depakote, do not stop taking the medicine without your doctor's advice. Seizure control is very important during pregnancy. The benefit of preventing seizures may outweigh any risks posed by taking divalproex sodium. There may be other seizure medications that can be more safely used during pregnancy. Follow your doctor's instructions about taking Depakote while you are pregnant. Depakote can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take Depakote?
Take Depakote exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Drink plenty of water while you are taking this medication. Your dose may need to be changed if you do not get enough fluids each day.
You may open the Depakote sprinkle capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow this mixture right away.
Do not crush, chew, break, or open a delayed-release or extended-release tablet or capsule. Swallow it whole.
To be sure Depakote is not causing harmful effects, your liver function will need to be tested. Visit your doctor regularly.
Do not stop using Depakote without first talking to your doctor, even if you feel fine. You may have increased seizures if you stop using Depakote suddenly. You may need to use less and less before you stop the medication completely. Wear a medical alert tag or carry an ID card stating that you take Depakote. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking a seizure medication.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include sleepiness or drowsiness, shallow breathing, weak pulse, or loss of consciousness.
What should I avoid while taking Depakote?
Drinking alcohol can increase certain side effects of Depakote. Depakote may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid exposure to sunlight or tanning beds. Depakote can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Depakote side effects
Seek emergency medical attention if the person taking Depakote has nausea, vomiting, upper stomach pain, or loss of appetite, low fever, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). These symptoms may be early signs of liver damage or pancreatitis.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
Get emergency medical help if you have any of these signs of an allergic reaction to Depakote: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these other serious side effects:
unexplained weakness with vomiting and confusion or fainting;
easy bruising or bleeding, blood in your urine;
fever, chills, body aches, swollen glands, flu symptoms;
urinating less than usual;
extreme drowsiness, lack of coordination, hallucinations;
double vision or back-and-forth movements of the eyes; or
severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Less serious Depakote side effects may include:
mild drowsiness or weakness;
diarrhea, constipation, upset stomach;
changes in your menstrual periods;
enlarged breasts, weight changes;
vision changes; or
unusual or unpleasant taste in your mouth.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Depakote side effects (in more detail)
What other drugs will affect Depakote?
Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for depression or anxiety can add to sleepiness caused by Depakote. Tell your doctor if you regularly use any of these medicines, or any other seizure medication.
Tell your doctor about all other medications you use, especially:
a blood thinner such as warfarin (Coumadin, Jantoven);
aspirin or acetaminophen (Tylenol);
clozapine (Clozaril, FazaClo);
meropenem (Merrem) or imipenem and cilastatin (Primaxin);
rifampin (Rifadin, Rimactane, Rifater); or
This list is not complete and other drugs may interact with Depakote. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More Depakote resources
- Depakote delayed-release tablets MedFacts Consumer Leaflet (Wolters Kluwer)
- Depakote Advanced Consumer (Micromedex) - Includes Dosage Information
- Depakote Prescribing Information (FDA)
- Divalproex Sodium Monograph (AHFS DI)
- divalproex sodium Advanced Consumer (Micromedex) - Includes Dosage Information
- Depakote ER Prescribing Information (FDA)
- Depakote ER extended-release tablets MedFacts Consumer Leaflet (Wolters Kluwer)
Compare Depakote with other medications
Where can I get more information?
- Your pharmacist can provide more information about Depakote.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Depakote only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2011 Cerner Multum, Inc. Version: 9.01. Revision Date: 7/14/2011 3:35:11 PM.