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Levetiracetam Pregnancy and Breastfeeding Warnings

Levetiracetam is also known as: Elepsia XR, Keppra, Keppra XR, Spritam

Levetiracetam Pregnancy Warnings

Extensive transfer of levetiracetam from mother to fetus has been reported. Physiological changes may gradually decrease the plasma levels of levetiracetam throughout pregnancy. The decrease is most notable in the third trimester. Pregnant patients should be monitored closely during pregnancy and the postpartum period particularly if the dose was changed during the pregnancy. To provide information regarding the effects of in utero exposure to levetiracetam, physicians are advised to recommend that pregnant patients taking levetiracetam enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry. This can be done by calling the toll free number 1-888-233-2334, and must be done by patients themselves. Information on the registry can also be found at the website

Levetiracetam has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of increased incidences of minor fetal skeletal abnormalities, retarded offspring growth, embryofetal mortality, and offspring behavioral alterations. There are no controlled data in human pregnancy. Levetiracetam is only recommended for use during pregnancy when the potential benefits justify the potential risk to the fetus.

Levetiracetam Breastfeeding Warnings

Levetiracetam is excreted into human milk. Because of the potential for serious adverse reactions in the nursing infant, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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