Ceftaroline Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Pneumonia

600 mg via IV infusion every 12 hours

Duration of therapy:
-Acute bacterial skin and skin structure infections (ABSSSI): 5 to 14 days
-Community-acquired bacterial pneumonia (CABP): 5 to 7 days

Approved indications:
-For the treatment of ABSSSI due to susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and -resistant isolates), Streptococcus pyogenes, S agalactiae, Escherichia coli, Klebsiella pneumoniae, and K oxytoca
-For the treatment of CABP due to susceptible isolates of S pneumoniae (including cases with concurrent bacteremia), S aureus (methicillin-susceptible isolates only), Haemophilus influenzae, K pneumoniae, K oxytoca, and E coli

Usual Adult Dose for Skin and Structure Infection

600 mg via IV infusion every 12 hours

Duration of therapy:
-Acute bacterial skin and skin structure infections (ABSSSI): 5 to 14 days
-Community-acquired bacterial pneumonia (CABP): 5 to 7 days

Approved indications:
-For the treatment of ABSSSI due to susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and -resistant isolates), Streptococcus pyogenes, S agalactiae, Escherichia coli, Klebsiella pneumoniae, and K oxytoca
-For the treatment of CABP due to susceptible isolates of S pneumoniae (including cases with concurrent bacteremia), S aureus (methicillin-susceptible isolates only), Haemophilus influenzae, K pneumoniae, K oxytoca, and E coli

Renal Dose Adjustments

CrCl greater than 50 mL/min: No adjustment needed
CrCl greater than 30 to 50 mL/min: 400 mg IV every 12 hours
CrCl 15 to 30 mL/min: 300 mg IV every 12 hours
End-stage renal disease (CrCl less than 15 mL/min): 200 mg IV every 12 hours

Liver Dose Adjustments

Data not available

Precautions

Consult WARNINGS section for dosing related precautions.

Dialysis

Hemodialysis: 200 mg IV every 12 hours

Comments:
-Because ceftaroline is hemodialyzable, it should be administered after hemodialysis on hemodialysis days.

CAPD: Data not available

Other Comments

Administration advice:
-Administer via IV infusion over 1 hour.
-Therapy duration should be guided by severity and site of infection and by patient's clinical and bacteriological progress.

Storage requirements:
-The manufacturer's product information should be consulted.

Reconstitution/preparation techniques:
-The manufacturer's product information should be consulted.
-Final volume for infusion into patients should be between 50 to 250 mL.

IV compatibility:
-Infusion solutions: 0.9% sodium chloride injection, 5% dextrose injection, 2.5% dextrose injection, 0.45% sodium chloride injection, Lactated Ringer's injection
-Compatibility with other drugs not established; should not mix with or physically add to solutions containing other drugs.

Patient advice:
-Avoid missing doses and complete the entire course of therapy.

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