Ceftaroline Side Effects

Not all side effects for ceftaroline may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to ceftaroline: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by ceftaroline. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking ceftaroline, check with your doctor or nurse immediately:

More common
  • Back, leg, or stomach pains
  • bleeding gums
  • chills
  • dark urine
  • difficulty with breathing
  • fever
  • general body swelling
  • headache
  • loss of appetite
  • nausea or vomiting
  • nosebleeds
  • pale skin
  • sore throat
  • unusual tiredness or weakness
  • yellowing of the eyes or skin
Less common
  • Abdominal or stomach tenderness
  • black, tarry stools
  • blood in the urine or stools
  • bluish color
  • changes in skin color
  • chest pain or discomfort
  • confusion
  • convulsions
  • cough
  • decreased frequency or amount of urine
  • diarrhea
  • difficulty with swallowing
  • dizziness
  • dry mouth
  • fast, irregular, pounding, or racing heartbeat or pulse
  • general tiredness and weakness
  • hives
  • increased blood pressure
  • increased thirst
  • itching
  • light-colored stools
  • lightheadedness, dizziness, or fainting
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • severe abdominal or stomach cramps and pain
  • shortness of breath
  • skin itching, rash, or redness
  • slow or irregular heartbeat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the face, throat, fingers, or lower legs
  • swollen glands
  • tenderness
  • tightness in the chest
  • troubled breathing
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • upper right abdominal or stomach pain
  • watery and severe diarrhea, which may also be bloody
  • weakness or heaviness of the legs
  • weight gain
  • wheezing

Some of the side effects that can occur with ceftaroline may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Blurred vision
  • difficulty having a bowel movement (stool)
  • flushed, dry skin fruit-like breath odor
  • hives or welts
  • increased hunger
  • increased urination
  • sweating
  • unexplained weight loss

For Healthcare Professionals

Applies to ceftaroline: intravenous powder for injection

General

The most common side effects reported in patients receiving ceftaroline were diarrhea, nausea, and rash. During clinical trials, serious side effects were reported in 7.5% of patients receiving ceftaroline and 7.7% of patients receiving comparator drugs. In both treatment groups, the most common serious side effects were in the respiratory and infection system organ classes. Treatment was discontinued due to side effects in 2.7% of patients receiving ceftaroline and 3.7% of patients receiving comparator drugs. Hypersensitivity was the most common side effect leading to discontinuation in both treatment groups.[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea (5%), nausea (4%), constipation (2%), vomiting (2%), abdominal pain (less than 2%), Clostridium difficile colitis (less than 2%)
Frequency not reported: C difficile associated diarrhea[Ref]

Dermatologic

Common (1% to 10%): Rash (3%), urticaria (less than 2%)[Ref]

Metabolic

Common (1% to 10%): Hypokalemia (2%), hyperglycemia (less than 2%), hyperkalemia (less than 2%)[Ref]

Cardiovascular

Common (1% to 10%): Phlebitis (2%), bradycardia (less than 2%), palpitations (less than 2%)[Ref]

Hepatic

Common (1% to 10%): Increased transaminases (2%), hepatitis (less than 2%)[Ref]

Hypersensitivity

Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported with beta-lactam antibacterials.[Ref]

Common (1% to 10%): Hypersensitivity (less than 2%), anaphylaxis (less than 2%)
Frequency not reported: Anaphylactoid reactions[Ref]

Renal

Common (1% to 10%): Renal failure (less than 2%)[Ref]

Hematologic

Common (1% to 10%): Anemia (less than 2%), eosinophilia (less than 2%), neutropenia (less than 2%), thrombocytopenia (less than 2%)[Ref]

Nervous system

Common (1% to 10%): Dizziness (less than 2%), convulsion (less than 2%)[Ref]

Other

Common (1% to 10%): Pyrexia (less than 2%)
Frequency not reported: Direct Coombs' test seroconversion[Ref]

References

1. "Product Information. Teflaro (ceftaroline)." Forest Pharmaceuticals, St. Louis, MO.

2. "Ceftaroline fosamil (Teflaro) - a new IV cephalosporin." Med Lett Drugs Ther 53 (2011): 5-6

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web4)