Skip to main content

Differin for Acne User Reviews (Page 4)

Differin has an average rating of 6.0 out of 10 from a total of 321 reviews for the treatment of Acne. 52% of reviewers reported a positive experience, while 37% reported a negative experience.

Reviews for Differin

  • howell
  • December 21, 2019

"I’m 20 years years old and have had break outs since I was about 16. I don’t necessarily have acne, but very bad break outs, mostly hormonal. I started doing research and found differin gel. Now, the reviews were extremely scattered. I saw plenty of good and bad reviews. I went out and got this gel at my local walmart. The first 1-2 weeks were completely fine,no difference in my skin at all. The 3-4 week mark hit, I was breaking out BAD. PAINFUL HUGE PIMPLES and my skin was dry too. I kept pushing and continued to use it, even though my confidence was out the window, I even struggled with wanting to leave my house. I’m on the 8 week mark right now, and my skin looks pretty damn good. Scarring, a few active spots. I like this product A LOT. I’m not even at the full 12 weeks yet and things are looking up for sure. If you have the patience to go through the terrible purging phase, then get this product. KEEP GOING, DO NOT STOP. IT WILL BE WORTH IT."

8 / 10
Was this helpful?YesNo
28 Report
  • Channie
  • Taken for 6 months to 1 year
  • December 20, 2019

"I had started using it about a year ago. Used for six weeks before my skin started to clear up a bit. That’s where it went downhill... I started to break out even worse and it was almost as if my skin started to become immune to it so I stop using it. Just recently started using it again, and as I suspected my skin started to clear up a bit but I can already feel the effects reversing. I hope others have better luck than I did"

6 / 10
Was this helpful?YesNo
2 Report
  • Racer...
  • December 17, 2019

"I've been using differin for 3 months. I'm 40 yrs old and have had acne my whole life. I also ND help with pigmentation and oiliness ,this is suppose to help. I started using it at night and morning. I never had any dryness or irritation. It has not helped my pigmentation at all. I think it has helped my current acne slightly and has definitely helped the oiliness on my cheek area decreasing my pore size. Didn't help oil and any other area. I notice that when I am using this I do not get any new breakouts. If I miss days I will feel a pimple coming under the skin and it may be a little red but as long as I put this on it as soon as I feel it, it disappears and never makes it to the surface. Differin is the only medication that has ever done that. I must say this is the best product I've used."

8 / 10
Was this helpful?YesNo
6 Report

Frequently asked questions

  • Krist...
  • Taken for 1 to 6 months
  • December 16, 2019

"If you have sensitive skin don't use this it made me break out in cystic painful acne I think it's the paraben in the medication"

1 / 10
Was this helpful?YesNo
4 Report
  • Skye
  • December 15, 2019

"Do not use this especially if your acne isn’t very bad. I would get a few spots around my mouth nothing much and when I used Differin it make huge red ones come up all over my face. I continued to use it for another 2 months as it’s supposed to get worse first but it never did get better and never worked and put me through lots of pain. Now I am stuck with dark scarring and texture all over my cheeks. I was using a recommended moisturiser so I don’t blame the products I put with it. Differin ruined my face completely I do not recommend"

1 / 10
Was this helpful?YesNo
10 Report

Are you taking this medicine?

  • Jen
  • Taken for 1 to 2 years
  • December 13, 2019

"I used Differin for about 1.5 years. The reason I started it was I had entered my 40's I wanted something that would help with skin texture and some painful cystic acne. I never had a retinization period or experienced any purge, but now after more than a year into it I am calling it quits on the advice of my aesthetician and dermatologist, both whom never recommend adapalene to their patients (I think that says something). It has dried out my skin to the point where my skin is over compensating for the oil that is being stripped away (and I have naturally oily skin), thus, making my pores look HUGE and oily. If you are over 30, I suggest not to use this, as it will dry out aging skin, even with moisturizer. This stuff pretty much destroyed my moisture barrier over time and now I'm left with trying to repair it and all the effects from it."

2 / 10
Was this helpful?YesNo
11 Report
  • Chris...
  • Taken for 1 to 6 months
  • November 30, 2019

"The purge I experienced lasted in two different waves from end of week 2 to week 6. Yikes. However, the acne from it was no worse than what I had been dealing with already on some of my worse breakouts. I seemed to be able to combat inflammation by using a benzoyl peroxide face wash and aloe vera gel as part of my routine. For me personally, dryness and skin flaking was far worse than the purge. It took about 7 weeks for my skin to adjust to adapalene, and even with two moisturizers layered on, I had the worst dryness and slight irritation. That said, once I hit 8 weeks, noticeable improvements started happening. About half of my comedones are gone, dryness is now manageable, and hyperpigmentation scars are starting to fade a little bit. I expect all of these areas to keep improving now that I'm getting closer to the 12 week mark. This was a process that had growing pains, but I am so glad to have stuck with it. Be patient, it will reward you!"

7 / 10
Was this helpful?YesNo
13 Report
  • Kale
  • November 27, 2019

"I've been using differin for a little over 2 months now. I was struggling with hormonal breakouts and closed comedones for a long time, and decided to go for it, because nothing else was really helping. I got rid of everything in my skincare routine with SA or glycolic acid in it and simplified it just to double cleansing with mild cleanser, a moisturizing gel and differin. I definitely had a purging phase, my skin looked the worse I ever remember it looking, I had acne all over my cheeks. I had a breakout of literally 8-9 cysts clustered on my chin. It made me feel really self conscious! However, I'm starting to see some real improvement, I'm not getting as many comedones, and the ones I did have mostly vanished. The acne I do get though, is kinda painful and appears on places I normally would never breakout in, like my temples. I realize it's a little early to be making judgements on it, but I feel confident that I'll continue to see more improvements with time"

8 / 10
Was this helpful?YesNo
7 Report
  • Tano
  • Taken for 6 months to 1 year
  • November 26, 2019

"Words cannot describe how much this has changed my life. I’m now 40 years old and my skins looks the best it’s ever looked. I’ve tried every product under the sun from prescriptions to over the counter for 20 years. Nothing ever worked. Finally I realized that Differin was available OTC, so I had nothing to lose. After about 6 weeks I noticed my acne slowly started subsiding. After about 12 weeks, I noticed my hyperpigmentation was starting to fade. And now, after about 6 months, I’ve noticed my old acne scars are starting to smooth out. Is this some sort of miracle gel? For me it is. Because it gave me my confidence back. I can now look in the mirror every morning and not be ashamed of my skin. So thank you Differin for a wonderful product."

10 / 10
Was this helpful?YesNo
6 Report
  • Anon
  • Taken for 1 to 6 months
  • November 25, 2019

"I have suffered with cystic acne on and off for years. In the past benzoyl peroxide and lymcacycle tablets have helped but following a recent terrible period of cysts on my chin I was recommended Differin. I have been using Differin for 6 weeks and can honestly say, even with the Purge in mind, my acne is the worst it has been in 20 years. My chin is a mess of scars, bumps, new cysts every week. I get that over a longer period it may help but like other reviewers on this site I'm simply not prepared to put up with this any longer and will return to Benzoyl peroxide. I just hope I can get back to where I was which was the odd cyst. Be careful what you wish for!"

1 / 10
Was this helpful?YesNo
6 Report
  • Hilbean
  • Taken for 1 to 6 months
  • November 24, 2019

"UPDATE: I had to quit. Just a quick reiteration of my back story: I had been benzoyl peroxide for a long while with ok results. I still would have 2-3 zits on my face sometimes (mostly around my time of the month) but looking back it wasn't too bad. I just started to notice my skin was looking dull and congested so thought I needed to change up. My dermatologist suggested Differin last time I saw her, so after much research I decided to give it a try. I knew there was going to be a purge phase so I thought I was prepared. I was not. TODAY: I look like I have a disease on my face. After week 8 and seeing no improvement and suddenly developing itchiness that was driving me crazy, I made an emergency appointment with my dermatologist. I am now on 3 medications to counteract the effects of differin. It may work for some but unfortunately I was not one of those people. I regret it so much. Please be cautious, because I now have months of recovery ahead of me."

1 / 10
Was this helpful?YesNo
9 Report
  • Liano
  • Taken for less than 1 month
  • November 18, 2019

"My face was so clear and suddenly I got acne all over my forehead, very small bumps. My dermatologist prescribed this to me and its amazing it's week 3 and the bumps are almost gone and my face is glowing and old acne marks are lighter. Everything is great, I think I'll continue using this for a while "

9 / 10
Was this helpful?YesNo
11 Report
  • CS_mom
  • Taken for 6 months to 1 year
  • November 17, 2019

"I have used Retinol for years, recently switched and gave Differin a try. I purged, and then waited, and waited. My skin was a mess for months. I couldn’t ever get it happy or calm, even after the purge period. Deep cystic acne combined with these weird superficial blemishes that I’ve never had. This is honestly one of the worst products I’ve ever used for my occasional hormonal acne and fine lines. I’ll stick with glycolic acid and retinol from now on."

2 / 10
Was this helpful?YesNo
13 Report
  • notre...
  • Taken for 1 to 6 months
  • November 16, 2019

"A bit of a backstory- earlier this year I started breaking out quite badly with cystic acne all over my forehead and chin. I was prescribed benzoyl peroxide, which cleared my face completely in a matter of months. However, everything came back when I stopped treatment. This time, however, benzoyl peroxide did not help, so I was prescribed Differin cream, about 8 weeks ago. I introduced it gradually, trying to avoid the dreaded "purge". My forehead and chin did clear up, mostly; however, I noticed that with the cream, the marks that are left after the inflammation take significantly longer to fade, and I have been getting acne in places where I haven't before. Overall, its effect is evident, and it does keep (most of) the violent cysts at bay, but my face is still far from clear."

7 / 10
Was this helpful?YesNo
1 Report
  • Sharon
  • Taken for 1 to 6 months
  • October 29, 2019

"I guess I’m one of those people who Differin does not work. I suggest if you are going to try this medication you purchase the small tube since this medicine is not cheap. I only have a few occasional breakouts, but wanted to find a product other than benzyl peroxide (BP)to get away from the bleaching effect. I gave it a 6 week try and like others who have left reviews here initially things looked positive. The “purging” seemed to clear my blocked pores, but I was having breakouts daily where I never had them before. After stopping for 5 days and going back to benzyl peroxide my skin has cleared and back to normal. I’m willing to put up with the side effects of BP for a third of the cost."

1 / 10
Was this helpful?YesNo
5 Report
  • Hilbean
  • Taken for 1 to 6 months
  • October 28, 2019

"I wanted to share my experience with Differin as someone in the middle of the dreaded acne purge. I am coming into 6 weeks and I have to say this has been the worse my skin has looked since I first started breaking out 17 years ago. I am not only getting white head that seem to burst in the most inopportune time, I am also getting a lot of actual raised acne. It is all happening in the majority of problem area. The worst thing is that it is happening in clusters. It seems to be more painful than my normal break-outs since they come hard and fast. They also subside fast, but as of right now....more seem to be not far behind. Right now I can't help but giving this 1 star because this is pure awfulness...plain and simple. That being said, I am moving forward using the medication. I will update next week and week 8 when most of the purging is supposed to be at an end."

1 / 10
Was this helpful?YesNo
17 Report
  • Anonymous
  • Taken for 1 to 6 months
  • October 21, 2019

"I've been using Differin for only 6 weeks and my skin isn't perfect but I can definitely see a difference and I can tell it'll get even clearer! I was really worried about the purging and the dryness but my dermatologist gave me minocycline (prescribed pill for acne) and also a really nice coconut oil based moisturizer and I haven't had any issues except a couple minor breakouts! I definitely recommend going to the dermatologist before using this product because they can give you products or tips to prevent any irritation!"

Was this helpful?YesNo
4 Report
  • Yaycl...
  • October 19, 2019

"I was prescribed Differin by my dermatologist in March 2019 and it has been the best decision I’ve made for my skin. I complained to her about my acne and how I had hyper pigmentation from it. When I started using Differin my skin was pretty sensitive for a week, it felt like I had a burn on my face but it was bearable. I wouldn’t say my skin purged like crazy because as I was getting more breakouts the acne got smaller right after. Mind you, my skin is usually oily and not sensitive. After about two months my skin was dramatically clearer. The red marks on my skin have also gotten lighter, but still haven’t gone away completely. I love waking up with clear and smooth skin because I wouldn’t have thought this was possible 7 months ago."

10 / 10
Was this helpful?YesNo
8 Report
  • Adult...
  • Taken for 1 to 6 months
  • October 17, 2019

"I am 38 years old and am suddenly dealing with large cystic acne after several years of clear skin. I have tried every topical treatment since age 17 and decided to try this one that it’s OTC. The retinoid purging process is definitely real and it’s ugly, but the texture of my skin truly is improving day by day, even with the large breakouts from the purge. I’m going to stick with it as it’s only been four weeks and I’m pretty confident it’s going to dramatically improve my skin’s texture and appearance over the next couple of months."

9 / 10
Was this helpful?YesNo
4 Report
  • HPD
  • October 16, 2019

"I've been using differin going 13 weeks now and I'm still breaking out in painful cystic acne EVERYWHERE. I've got 10+ cystic pimple on my forehead whereas I've never had them there before, and it's been two weeks and they're still not gone. It's painful, itchy, makes you self-conscious AF. I hate it. If your skin isn't too bad but you're thinking about it, find an alternative. It's not worth it. I feel like I have depression because of this."

1 / 10
Was this helpful?YesNo
50 Report
  • Rose
  • October 15, 2019

"Started off with few blind pimples on my chin and jaw line started using this Differin and formed huge cysts on places I never even got acne before. It started to get better after about a month and then got sooooo bad but kept using it until like 4 months. Now my skin is the worst I’ve ever seen it with pimples constantly showing up everywhere in the same spots even tho I discontinued use months ago."

1 / 10
Was this helpful?YesNo
9 Report
  • Leeben
  • Taken for 1 to 6 months
  • October 13, 2019

"I started using differin at 48 years old. I really got into skin care in the last 8 years and could never get rid of my blackheads and bumpy skin texture. Seriously, I’ve tried all OTC products from drug store to department store. The dermatologist told me to try differin and it might even help my wrinkles. Differin has cleared my skin to the best texture I’ve ever had I without one blackhead. My skin is so soft. I’ve been using it for seven months. I started slow using every 2-3 days because of redness and burning. I found an extremely heavy duty moisturizer without any retinoids in it which helped me work up to using it daily. Make sure you’re not exfoliating with any other products in the first month or two. If you’re burning and red then skip a day or two. It takes your skin a while to adjust but the outcome is so worth it. Some of my sun spots have lightened as well. As far as wrinkles go, I’d say they are a tad better."

8 / 10
Was this helpful?YesNo
8 Report
  • Barbie...
  • Taken for 10 years or more
  • October 9, 2019

"I got Differin Gel about 20 years ago. At that time it was available by prescription only. It took a few months before my skin cleared up. It really works!"

10 / 10
Was this helpful?YesNo
3 Report
  • skmar
  • Taken for 1 to 6 months
  • October 3, 2019

"Differin burned my skin and destroyed my moisture barrier. I've stopped using and am now a week off of it, and ALL other actives and cleansers and am still red, itchy, and have super visible pores. I guess I am just one of the people who are extra sensitive or allergic to retinoids as I've heard many people have had a wonderful experience with it."

1 / 10
Was this helpful?YesNo
6 Report
  • Ers
  • Taken for less than 1 month
  • September 25, 2019

"I love this stuff. It’s working really well for me and was a fairly smooth transition. I have some advice—definitely layer this over a lotion. Still works really well but prevents irritation!"

10 / 10
Was this helpful?YesNo
4 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

Learn more about Acne

Care guides

Symptoms and treatments

Medicine.com guides (external)