Differin Side Effects
Generic Name: adapalene topical
Note: This document contains side effect information about adapalene topical. Some of the dosage forms listed on this page may not apply to the brand name Differin.
Some side effects of Differin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to adapalene topical: topical cream, topical gel/jelly, topical lotion, topical solution, topical swab
Along with its needed effects, adapalene topical (the active ingredient contained in Differin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking adapalene topical:More common - especially during the first month of use
- Burning sensation or stinging of skin
- dryness and peeling of skin
- itching of skin
- redness of skin
Some side effects of adapalene topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Rare - more common during the first month of use
- Worsening of acne
For Healthcare Professionals
Applies to adapalene topical: topical cream, topical gel, topical lotion, topical solution, topical swab
Local side effects have included erythema, scaling, dryness, burning, and pruritus in 30 to 60% of patients. Persistent pruritus and stinging have been reported in up to 24% of patients. Skin irritation, acne flares, sunburn, and skin discoloration have been reported rarely (less than 1%).
Erythema, scaling, dryness, burning, and pruritus usually occur during the first 2 to 4 weeks of therapy and lessen with continued use. Burning and itching immediately after application occurs in approximately 20% to 30% of patients.
All local side effects occurring with adapalene topical appear to be reversible upon discontinuation of therapy.
Dermatologic side effects have rarely included dermatitis, contact dermatitis, rash and eczema.
Ocular side effects have rarely included eyelid edema and conjunctivitis.
More about Differin (adapalene topical)
- Differin cream
- Differin lotion
- Differin pads
- Differin solution
- Differin Topical (Advanced Reading)
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