Trimipramine

Generic Name: trimipramine (trye-MIP-ra-meen)
Brand Name: Surmontil

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using trimipramine outweigh the risks.

Family and caregivers must closely watch patients who take trimipramine. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.

Trimipramine is not approved for use in children. Talk with the doctor.


Trimipramine is used for:

Treating depression. It may also be used for other conditions as determined by your doctor.

Trimipramine is a tricyclic antidepressant. It works by increasing the activity of certain chemicals in the brain that help elevate mood.

Do NOT use trimipramine if:

  • you are allergic to any ingredient in trimipramine or to similar medicines
  • you have taken furazolidone, linezolid, or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
  • you are recovering from a recent heart attack

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: Depression, the Risk of Suicide, and Treatment Options

Before using trimipramine:

Some medical conditions may interact with trimipramine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you drink alcohol-containing beverages daily or you have a history of alcohol abuse
  • if you have an overactive thyroid, increased pressure in the eye or glaucoma, heart problems, a fast or irregular heartbeat, kidney or liver problems, diabetes, the blood disease porphyria, an enlarged prostate, or difficulty urinating
  • if you have a history of seizures, suicidal thoughts or behavior, bipolar disorder, or any other mental disorders
  • if you are undergoing electroshock therapy or are scheduled to have any surgery
  • if you are taking a medicine that contains methylene blue

Some MEDICINES MAY INTERACT with trimipramine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Azole antifungals (eg, fluconazole), cimetidine, duloxetine, flecainide, methylphenidate, mibefradil, phenothiazines (eg, chlorpromazine), propafenone, quinidine, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), or terbinafine because they may increase the risk of trimipramine's side effects
  • Arsenic, astemizole, droperidol, furazolidone, linezolid, MAOIs (eg, phenelzine), pimozide, quinolone antibiotics (eg, ciprofloxacin), streptogramins (eg, dalfopristin), terfenadine, tramadol, or ziprasidone because the risk of high blood pressure, serious heart problems (eg, irregular heartbeat), or seizures may be increased
  • Barbiturates (eg, phenobarbital) or phenytoin because they may decrease trimipramine's effectiveness
  • Anticholinergics (eg, benztropine), anticoagulants (eg, warfarin), carbamazepine, or sympathomimetics (eg, phenylephrine) because the risk of their side effects may be increased by trimipramine
  • Clonidine, guanethidine, or guanfacine because their effectiveness may be decreased by trimipramine

This may not be a complete list of all interactions that may occur. Ask your health care provider if trimipramine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use trimipramine:

Use trimipramine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Trimipramine comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get trimipramine refilled.
  • Take trimipramine by mouth with or without food.
  • Taking trimipramine at bedtime may help reduce side effects (eg, daytime drowsiness). Discuss this possibility with your doctor.
  • It may take 1 to 3 weeks before you notice the effect of trimipramine. Continue to use trimipramine even if you feel well. Do not miss any doses.
  • If you miss a dose of trimipramine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you take 1 dose daily at bedtime, do not take the missed dose the next morning.

Ask your health care provider any questions you may have about how to use trimipramine.

Important safety information:

  • Trimipramine may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use trimipramine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using trimipramine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Trimipramine may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Do not become overheated in hot weather or while you are being active; heatstroke may occur.
  • Diabetes patients - Trimipramine may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Children, teenagers, and young adults who take trimipramine may be at increased risk for suicidal thoughts or actions. Watch all patients who take trimipramine closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
  • Serotonin syndrome is a possibly fatal syndrome that can be caused by trimipramine. Your risk may be greater if you take trimipramine with certain other medicines (eg, triptans, MAOIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.
  • Trimipramine may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to trimipramine. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Some people may be at risk for eye problems from trimipramine. Your doctor may want you to have an eye exam to see if you are at risk for these eye problems. Call your doctor right away if you have eye pain, vision changes, or swelling or redness in or around the eye.
  • Tell your doctor or dentist that you take trimipramine before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including blood counts, may be performed while you use trimipramine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use trimipramine with caution in the ELDERLY (especially those with cardiac disease); they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: It is not known if trimipramine can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using trimipramine while you are pregnant. It is not known if trimipramine is found in breast milk. Do not breast-feed while taking trimipramine.

If you suddenly stop taking trimipramine, you may experience WITHDRAWAL symptoms, including headache, nausea, and tiredness.

Possible side effects of trimipramine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth; excitement; headache; impotence; nausea; nightmares; pupil dilation; sensitivity to sunlight; sweating; tiredness; upset stomach; vomiting; weakness; weight loss or gain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; changes in sex drive; chest pain; confusion; constipation; fast, slow, or irregular heartbeat; fainting; fever; frequent or difficult urination; hallucinations; impulsive behavior or other unusual changes in behavior; jaw, neck, or muscle spasms; mental or mood changes (eg, increased anxiety, mood swings, agitation, irritability, nervousness, restlessness); panic attacks; ringing in the ears; seizures; severe dizziness or drowsiness; sore throat; stomach pain; suicidal thinking or behavior; swelling of the testicles; tremor; trouble sleeping; trouble walking or keeping your balance; twitching of the face or tongue; uncontrolled movements of arms and legs or stiffness; unusual bleeding or bruising; worsening of depression; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of trimipramine:

Store trimipramine at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store in a tightly sealed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep trimipramine out of the reach of children and away from pets.

General information:

  • If you have any questions about trimipramine, please talk with your doctor, pharmacist, or other health care provider.
  • Trimipramine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take trimipramine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about trimipramine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to trimipramine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using trimipramine.

Issue Date: November 5, 2014
Database Edition 14.4.1.002
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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