Trimipramine Side Effects

Brand Names: Surmontil

Please note - some side effects for Trimipramine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Trimipramine - for the Consumer

Trimipramine

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Trimipramine:

Dizziness; drowsiness; dry mouth; excitement; headache; impotence; nausea; nightmares; pupil dilation; sensitivity to sunlight; sweating; tiredness; upset stomach; vomiting; weakness; weight loss or gain.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; changes in sex drive; chest pain; confusion; constipation; fast, slow, or irregular heartbeat; fainting; fever; frequent or difficult urination; hallucinations; impulsive behavior or other unusual changes in behavior; jaw, neck, or muscle spasms; mental or mood changes (eg, increased anxiety, mood swings, agitation, irritability, nervousness, restlessness); panic attacks; ringing in the ears; seizures; severe dizziness or drowsiness; sore throat; stomach pain; suicidal thinking or behavior; swelling of the testicles; tremor; trouble sleeping; trouble walking or keeping your balance; twitching of the face or tongue; uncontrolled movements of arms and legs or stiffness; unusual bleeding or bruising; worsening of depression; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side Effects by Body System - for Healthcare Professionals

Cardiovascular

Cardiovascular side effects including hypertension, hypotension, tachycardia, palpitation, myocardial infarction, arrhythmias, heart block, and stroke have been reported.

Nervous system

Nervous system side effects including numbness, tingling, paresthesias of the extremities, incoordination, ataxia, tremors, peripheral neuropathy, extrapyramidal symptoms, seizures, alterations in EEG patterns, sleep abnormalities, and tinnitus have been reported.

Nearly all selective serotonin reuptake inhibitors, mixed serotonin/norepinephrine reuptake inhibitors, and tricyclic antidepressants cause sleep abnormalities to some extent. These antidepressants have marked dose-dependent effects on rapid eye movement (REM) sleep, causing reductions in the overall amount of REM sleep over the night and delays the first entry into REM sleep (increased REM sleep onset latency (ROL)), both in healthy subjects and depressed patients. The antidepressants that increase serotonin function appear to have the greatest effect on REM sleep. The reduction in REM sleep is greatest early in treatment, but gradually returns towards baseline during long-term therapy; however, ROL remains long. Following discontinuation of therapy the amount of REM sleep tends to rebound. Some of these drugs (i.e., bupropion, mirtazapine, nefazodone, trazodone, trimipramine) appear to have a modest or minimal effect on REM sleep.

Psychiatric

Psychiatric side effects including states of confusion (especially in the elderly) with hallucinations, disorientation, delusions, anxiety, restlessness, agitation, insomnia, nightmares, hypomania, and exacerbation of psychosis have been reported.

Genitourinary

Chronic animal studies have reported occasional evidence of degeneration of seminiferous tubules at the highest dose tested.

Genitourinary side effects including urinary retention, urinary frequency, delayed micturition, and dilation of the urinary tract have been reported.

Endocrine

Endocrine side effects including gynecomastia in the male, breast enlargement and galactorrhea in the female, increased or decreased libido, impotence, testicular swelling, elevation or depression of blood sugar levels, and syndrome of inappropriate antidiuretic hormone secretion have been reported.

Gastrointestinal

Gastrointestinal side effects including nausea, vomiting, anorexia, epigastric distress, diarrhea, peculiar taste, stomatitis, abdominal cramps, black tongue, dry mouth, constipation, parotid swelling, and paralytic ileus have been reported. Sublingual adenitis has rarely been reported.

Hypersensitivity

Hypersensitivity side effects including skin rash, petechiae, urticaria, itching, photosensitization, and edema of the face and tongue have been reported.

Hematologic

It is recommended that leukocyte and differential counts be performed in any patient who develops a fever and soar throat during therapy. The drug should be discontinued if there is evidence of a pathologic neutrophil depression.

Hematologic side effects including bone marrow depression have been reported. Bone marrow depression has included agranulocytosis, eosinophilia, purpura, and thrombocytopenia.

Hepatic

Hepatic side effects including jaundice (simulating obstructive) and altered liver function have been reported.

General

General side effects including weight gain or weight loss, drowsiness, dizziness, weakness, fatigue, and headache have been reported.

Dermatologic

Dermatologic side effects including perspiration, flushing, and alopecia have been reported.

Ocular

Ocular side effects including blurred vision, disturbances of accommodation, and mydriasis have been reported.

Other

Although these symptoms have been reported to occur following abrupt cessation of treatment, this is not felt to be indicative of an addiction to the drug.

Other side effects include nausea, headache, and malaise which have been reported to sometimes occur following abrupt cessation of treatment.

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