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Trimipramine Side Effects

It is possible that some side effects of trimipramine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to trimipramine: oral capsule, oral tablet

As well as its needed effects, trimipramine may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking trimipramine, check with your doctor immediately:

Incidence not known
  • Abdominal or stomach pain
  • agitation
  • black, tarry stools
  • bleeding or bruising
  • blood in the urine or stools
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • clay-colored stools
  • cold sweats
  • confusion about identity, place, and time
  • continuing ringing, buzzing, or other unexplained noise in the ears
  • convulsions
  • cool, pale skin
  • cough or hoarseness
  • dark urine
  • decrease in the frequency of urination
  • decreased urine output or volume
  • depression
  • difficulty in passing urine (dribbling)
  • difficulty with speaking
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • double vision
  • drooling
  • dry mouth
  • false beliefs that cannot be changed by facts
  • fast, pounding, or irregular heartbeat or pulse
  • feeling of warmth
  • feeling that others are watching you or controlling your behavior
  • feeling that others can hear your thoughts
  • feeling, seeing, or hearing things that are not there
  • fever with or without chills
  • flushed, dry skin
  • fruit-like breath odor
  • general feeling of tiredness or weakness
  • headache
  • hearing loss
  • hostility
  • hyperventilation
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • increased hunger
  • increased need to urinate
  • increased thirst
  • increased urination
  • irritability
  • itching or rash
  • lack of coordination
  • lethargy
  • loss of appetite
  • loss of balance control
  • lower back or side pain
  • mood or mental changes
  • muscle spasm or jerking of all extremities
  • muscle trembling or stiffness
  • muscle twitching
  • nausea
  • nightmares
  • pain or discomfort in the arms, jaw, back, or neck
  • painful or difficult urination
  • passing urine more often
  • pinpoint red or purple spots on the skin
  • pounding in the ears
  • rapid weight gain
  • redness of the face, neck, arms, and occasionally, upper chest
  • restlessness
  • shakiness and unsteady walk
  • shuffling walk
  • slow speech
  • slurred speech
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiffness of the limbs
  • sudden loss of consciousness
  • sweating
  • swelling of the face, ankles, legs, or hands
  • swollen glands
  • talking, feeling, and acting with excitement
  • trouble in holding or releasing urine
  • trouble sleeping
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
  • unpleasant breath odor
  • unsteadiness, awkwardness, trembling, or other problems with muscle control or coordination
  • unusual behavior
  • unusual tiredness or weakness
  • vomiting of blood
  • weakness in the arms, hands, legs, or feet
  • weight gain or loss
  • yellow eyes or skin

Some trimipramine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known
  • Abdominal or stomach cramps
  • bigger, dilated, or enlarged pupils (black part of the eye)
  • black tongue
  • bloating
  • decreased interest in sexual intercourse
  • diarrhea
  • difficulty having a bowel movement (stool)
  • disturbance of accommodation
  • enlargement of the breast
  • hair loss or thinning of the hair
  • heartburn
  • hives or welts
  • inability to have or keep an erection
  • increase in sexual ability, desire, drive, or performance
  • increased sensitivity of the eyes to light
  • increased sensitivity of the skin to sunlight
  • loss in sexual ability, desire, drive, or performance
  • pain or discomfort in the chest, upper stomach, or throat
  • peculiar taste
  • redness or other discoloration of the skin
  • severe sunburn
  • small red or purple spots on the skin
  • swelling of the breasts or breast soreness in both women and men
  • swelling of the testicles
  • swelling or inflammation of the mouth
  • swollen, painful, or tender lymph glands in the neck
  • unexpected milk flow from the breasts

For Healthcare Professionals

Applies to trimipramine: compounding powder, oral capsule


The most commonly reported side effects were tremors, dizziness, headache, dry mouth, constipation, and nausea.[Ref]


Frequency not reported: States of confusion (especially in the elderly) with hallucinations, disorientation, delusions, anxiety, restlessness, agitation, insomnia, nightmares, hypomania, exacerbation of psychosis, suicidal ideation, suicidal behaviors[Ref]

Nervous system

Frequency not reported: Numbness, tingling, paraesthesias of the extremities, incoordination, ataxia, tremors, peripheral neuropathy, extrapyramidal symptoms, seizures, alterations in EEG patterns, tinnitus, drowsiness, dizziness, headache, peripheral neuropathy[Ref]


Frequency not reported: Hypertension, hypotension, tachycardia, palpitation, myocardial infarction, arrhythmias, heart block, stroke, flushing[Ref]


Frequency not reported: Skin rash, petechiae, urticaria, itching, photosensitization, edema of the face and tongue[Ref]


Frequency not reported: Urinary retention, urinary frequency, delayed micturition, dilation of the urinary tract[Ref]


Frequency not reported: Gynecomastia in the male, breast enlargement and galactorrhea in the female, increased or decreased libido, impotence, testicular swelling, elevation or depression of blood sugar levels, syndrome of inappropriate antidiuretic hormone secretion[Ref]


Frequency not reported: Nausea, vomiting, anorexia, epigastric distress, diarrhea, peculiar taste, stomatitis, abdominal cramps, black tongue, dry mouth, constipation, parotid swelling, paralytic ileus, sublingual adenitis[Ref]


Frequency not reported: Bone marrow depression including agranulocytosis, eosinophilia, purpura, thrombocytopenia[Ref]


Frequency not reported: Jaundice (simulating obstructive), altered liver function[Ref]


Frequency not reported: Perspiration, sweating, alopecia[Ref]


Frequency not reported: Blurred vision, disturbances of accommodation, mydriasis[Ref]


Frequency not reported: Malaise, weakness, fatigue[Ref]


Frequency not reported: Weight gain or loss[Ref]


1. "Product Information. Surmontil (trimipramine)" Wyeth-Ayerst Laboratories, Philadelphia, PA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.