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Moduretic

Generic Name: amiloride/hydrochlorothiazide (a-MILL-oh-ride/hye-droe-klor-oh-THYE-a-zide)
Brand Name: Moduretic

Moduretic can increase potassium levels in your body. This is more likely to occur in elderly patients, patients who are severely ill, or patients with kidney problems and diabetes. If not treated, high potassium levels can be fatal. Potassium levels must be closely monitored in people with any of these problems or illnesses. Lab tests will be required so be sure to keep appointments. If you develop muscle weakness or an unusual heartbeat, notify your doctor immediately.


Moduretic is used for:

Treating fluid retention (edema) and high blood pressure. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.

Moduretic is a diuretic (water pill) and is a combination of a potassium-sparing diuretic (amiloride) and a thiazide diuretic (hydrochlorothiazide). It works by making the kidneys eliminate sodium (salt) and water from the body, which helps to lower blood pressure. The amiloride component helps minimize potassium loss.

Do NOT use Moduretic if:

  • you are allergic to any ingredient in Moduretic or any other sulfonamide (eg, sulfamethoxazole)
  • you are unable to urinate, have severely decreased kidney function, or high blood potassium
  • you are taking other potassium-sparing diuretics (eg, spironolactone), potassium supplements, salt substitutes containing potassium, or dofetilide

Contact your doctor or health care provider right away if any of these apply to you.

Before using Moduretic:

Some medical conditions may interact with Moduretic. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have cirrhosis or liver problems, diabetes, gout, kidney problems or kidney stones, asthma, heart problems, or systemic lupus erythematosus (SLE or lupus)
  • if you have elevated blood acid, low folic acid levels, or electrolyte problems, or are dehydrated

Some MEDICINES MAY INTERACT with Moduretic. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Potassium-sparing diuretics (eg, spironolactone), potassium supplements, or salt substitutes containing potassium because high blood potassium levels may occur and cause listlessness, confusion, abnormal skin sensations of the arms and legs, heaviness of limbs, slowed heart rate, irregular heart rhythm, or stopping of the heart
  • Cholestyramine or colestipol because they may decrease Moduretic's effectiveness
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, indomethacin) because they may decrease Moduretic's effectiveness of Moduretic may be decreased and the risk of kidney problems may be increased
  • Barbiturates (eg, phenobarbital), certain chemotherapy medicines, corticosteroids (eg, prednisone), digoxin, dofetilide, ketanserin, narcotic pain medicines (eg, codeine), or medicines for high blood pressure because the risk of their side effects may be increased by Moduretic
  • Diazoxide, lithium, or nondepolarizing neuromuscular blockers (eg, pancuronium) because their actions and the risk of their side effects may be increased by Moduretic
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) because the risk of high blood potassium and kidney problems may be increased by Moduretic
  • Diabetes medicines (eg, glipizide) or insulin because their effectiveness may be decreased by Moduretic

This may not be a complete list of all interactions that may occur. Ask your health care provider if Moduretic may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Moduretic:

Use Moduretic as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Moduretic by mouth with food.
  • Moduretic may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • If you miss a dose of Moduretic, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Moduretic.

Important safety information:

  • Moduretic may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Moduretic with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Moduretic may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • Moduretic may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Moduretic. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take Moduretic before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients - Moduretic may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Lab tests, including liver function, kidney function, lung function, blood pressure, and fasting blood glucose, may be performed while you use Moduretic. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Moduretic should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Moduretic while you are pregnant. It is not known if Moduretic is found in breast milk. Do not breast-feed while taking Moduretic.

Possible side effects of Moduretic:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in blood sugar; constipation; dizziness; fatigue; headache; inflammation of a salivary gland; loss of appetite; nausea; sensitivity to sunlight; stomach pain; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dry mouth; excessive thirst; impotence; leg or muscle cramps; mental confusion; rapid, weak, or irregular heartbeat; stomach pain; urination problems; vomiting; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include excessive urination; flushed face; lightheadedness especially upon standing; nausea; vomiting; weakness.

Proper storage of Moduretic:

Store Moduretic at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Moduretic out of the reach of children and away from pets.

General information:

  • If you have any questions about Moduretic, please talk with your doctor, pharmacist, or other health care provider.
  • Moduretic is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Moduretic or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Moduretic. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Moduretic. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Moduretic.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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