Amiloride / Hydrochlorothiazide Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Congestive Heart Failure

Initial dose: 1 tablet orally once a day with meals.
Maintenance dose: 1 to 2 tablets once a day or 1 tablet twice a day.
The maximum recommended dose is 2 tablets/day.

Usual Adult Dose for Hypertension

Initial dose: 1 tablet orally once a day with meals.
Maintenance dose: 1 to 2 tablets once a day or 1 tablet twice a day.
The maximum recommended dose is 2 tablets/day.

Renal Dose Adjustments

Hydrochlorothiazide is generally not effective in patients with severe renal insufficiency since it is not expected to be filtered into the renal tubule when glomerular filtration rate is less than 25 mL/min. Also, hyperkalemia is more likely to occur in patients with renal impairment and dosage adjustments should be made cautiously with careful monitoring of serum potassium levels.

Liver Dose Adjustments

Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

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