Medication Guide App

Dolasetron

Generic Name: dolasetron (doe-LAS-e-tron)
Brand Name: Anzemet

Dolasetron is used for:

Preventing and treating nausea and vomiting after surgery in adults and children 2 years old and older.

Dolasetron is a serotonin 5-HT3 receptor blocker. It works by blocking a substance thought to be a cause of nausea and vomiting in certain situations.

Do NOT use dolasetron if:

  • you are allergic to any ingredient in dolasetron
  • you are using dolasetron to prevent nausea and vomiting caused by cancer chemotherapy
  • you have a certain type of irregular heartbeat (congenital long QT syndrome), or uncorrected low blood potassium or magnesium levels
  • you have or are at risk of complete heart block and do not have a pacemaker
  • you are taking apomorphine or nilotinib

Contact your doctor or health care provider right away if any of these apply to you.

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Before using dolasetron:

Some medical conditions may interact with dolasetron. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to another serotonin 5-HT3 receptor blocker (eg, ondansetron, granisetron)
  • if you have a history of heart problems (eg, slow or irregular heartbeat, sick sinus syndrome, a heart attack, heart failure), kidney problems, or low potassium or magnesium levels in the blood
  • if a member of your family has a history of a certain type of irregular heartbeat (congenital long QT syndrome)
  • if you are taking medicines that may cause certain types of irregular heartbeat (eg, flecainide, verapamil, quinidine)

Some MEDICINES MAY INTERACT with dolasetron. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anthracyclines (eg, doxorubicin), antiarrhythmics (eg, amiodarone, dofetilide, sotalol), arsenic, astemizole, atenolol, bepridil, chloroquine, cimetidine, cisapride, diuretics (eg, furosemide), domperidone, droperidol, halofantrine, haloperidol, histone deacetylase inhibitors (eg, romidepsin), iloperidone, ketolides (eg, telithromycin), lithium, macrolides (eg, erythromycin), maprotiline, methadone, nilotinib, paliperidone, pentamidine, phenothiazines (eg, thioridazine), pimozide, quinolones (eg, levofloxacin), streptogramins (eg, quinupristin/dalfopristin), terfenadine, tetrabenazine, tricyclic antidepressants (eg, amitriptyline), tyrosine kinase inhibitors (eg, sunitinib), or ziprasidone because the risk of irregular heart rhythm is increased
  • Apomorphine because the risk of severe low blood pressure or loss of consciousness may be increased
  • Rifampin because it may decrease dolasetron's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if dolasetron may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use dolasetron:

Use dolasetron as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Dolasetron is usually administered as an injection at your doctor's office, hospital, or clinic.
  • Do not use dolasetron if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of dolasetron, contact your doctor right away.

Ask your health care provider any questions you may have about how to use dolasetron.

Important safety information:

  • Dolasetron may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use dolasetron with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Dolasetron may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Do NOT use more than the recommended dose without checking with your doctor.
  • Tell your doctor or dentist that you use dolasetron before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including electrocardiograms (ECGs), and blood potassium and magnesium levels, may be performed while you use dolasetron. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use dolasetron with caution in the ELDERLY; they may be more sensitive to its effects, especially irregular heartbeat.
  • Dolasetron should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
  • Caution is advised when using dolasetron in CHILDREN; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using dolasetron while you are pregnant. It is not known if dolasetron is found in breast milk. If you are or will be breast-feeding while you use dolasetron, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of dolasetron:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in heartbeat (including fast or slow heartbeat) or irregular heartbeat; chest pain; fainting; lightheadedness; numbness or pain of an arm or leg; pounding in the chest; shortness of breath; sudden, severe headache, stomach pain, dizziness, or vomiting; sudden vision changes; urination problems.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; irregular heartbeat; severe dizziness.

Proper storage of dolasetron:

Dolasetron is usually handled and stored by a health care provider. If you are using dolasetron at home, store dolasetron as directed by your pharmacist or health care provider. Do not store in the bathroom. Keep dolasetron out of the reach of children and away from pets.

General information:

  • If you have any questions about dolasetron, please talk with your doctor, pharmacist, or other health care provider.
  • Dolasetron is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take dolasetron or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about dolasetron. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to dolasetron. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using dolasetron.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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