Dolasetron Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Nausea/Vomiting - Chemotherapy Induced

100 mg orally may be given for prevention within one hour before chemotherapy.

Approved indication: For the prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy (including initial and repeat courses) in adults and children age 2 and older.

Usual Adult Dose for Nausea/Vomiting - Postoperative

12.5 mg IV given for prevention 15 minutes before the cessation of anesthesia or for treatment as soon as nausea or vomiting presents.

Approved indications: For the prevention or treatment of postoperative nausea and/or vomiting.

Usual Pediatric Dose for Nausea/Vomiting - Postoperative

2 years and older: 0.35 mg/kg (maximum: 12.5 mg) IV given for prevention 15 minutes before the cessation of anesthesia or for treatment as soon as nausea or vomiting presents.
Alternatively, 1.2 mg/kg (maximum: 100 mg) orally may be given for prevention within 2 hours before surgery.

Approved indications: For the prevention or treatment of postoperative nausea and/or vomiting in pediatric patients 2 years and older.

Usual Pediatric Dose for Nausea/Vomiting - Chemotherapy Induced

2 years and older:
1.8 mg/kg (maximum of 100 mg) orally within one hour before chemotherapy
Maximum dose: 100 mg

For children who cannot swallow tablets or in whom the 100 mg tablet is inappropriate based on their weight, the injection solution may be mixed into apple or apple-grape juice and taken orally. The mixture is stable for up to 2 hours at room temperature. However, due to dose dependent QT prolongation, the IV solution is contraindicated in adult and pediatric patients for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy.

Approved indication: For the prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy (including initial and repeat courses) in pediatric patients 2 years and older.

Renal Dose Adjustments

No adjustment recommended, however, ECG monitoring is recommended.

Liver Dose Adjustments

No adjustment recommended

Dose Adjustments

Dolasetron should be administered with caution in pediatric patients who have or may develop prolongation of cardiac conduction intervals, particularly QTc. Rare cases of sustained supraventricular and ventricular arrhythmias, cardiac arrest leading to death, and myocardial infarction have been observed in children and adolescents.

No differences in safety and effectiveness have been reported between geriatric and younger patients, but greater sensitivity of some elderly individuals cannot be ruled out.

Precautions

Consult WARNINGS section for dosing related precautions.

Dialysis

It is unknown if dolasetron is removed by hemodialysis or peritoneal dialysis.

Other Comments

Dolasetron injection may be used for oral administration in children. Mix dose in apple or apple-grape juice. The diluted product may be kept at room temperature and used within 2 hours of preparation.

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