Amoxapine

Generic Name: amoxapine (a-MOX-a-peen)
Brand Name: Generic only. No brands available.

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using amoxapine outweigh the risks.

Family and caregivers must closely watch patients who take amoxapine. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.

Amoxapine is not approved for use in children. Talk with the doctor.


Amoxapine is used for:

Treating depression. It may be also be used for other conditions as determined by your doctor.

Amoxapine is a tricyclic antidepressant. It works by increasing the activity of certain chemicals in the brain, which helps to elevate mood.

Do NOT use amoxapine if:

  • you are allergic to any ingredient in amoxapine
  • you are recovering from a heart attack
  • you are taking or have taken linezolid or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: Depression, the Risk of Suicide, and Treatment Options

Before using amoxapine:

Some medical conditions may interact with amoxapine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have any allergies to medicines, foods, or other substances
  • if you drink alcohol-containing beverages daily or you have a history of alcohol abuse
  • if you have a history of heart problems, thyroid problems, glaucoma or increased pressure in the eye, blood problems, an enlarged prostate, or problems urinating
  • if you have a history of seizures, suicidal thoughts or behavior, bipolar disorder, or any other mental disorders
  • if you are undergoing electroshock therapy or are scheduled to have any surgery
  • if you are taking a medicine that contains methylene blue

Some MEDICINES MAY INTERACT with amoxapine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Antiarrhythmics (eg, propafenone, flecainide), carbamazepine, cimetidine, fluconazole, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) H1 antagonists (eg, astemizole), macrolides or ketolides (eg, erythromycin), linezolid, mibefradil, MAOIs (eg, phenelzine), phenothiazines (eg, thioridazine), quinidine, or terbinafine because side effects, such as sedation, low blood pressure, and severe heart problems, may be increased
  • Anticoagulants (eg, warfarin) or sympathomimetics (eg, albuterol, amphetamine, pseudoephedrine) because actions and side effects may be increased by amoxapine
  • Clonidine, guanethidine, or guanfacine because effectiveness may be decreased by amoxapine

This may not be a complete list of all interactions that may occur. Ask your health care provider if amoxapine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use amoxapine:

Use amoxapine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Amoxapine comes with an additional patient information sheet called a Medication Guide. Read it carefully and reread it each time you get amoxapine refilled.
  • Take amoxapine by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Continue to take amoxapine even if you feel better. It may take several weeks before you feel the full benefit of amoxapine.
  • Taking amoxapine at bedtime may help reduce side effects.
  • Do not miss any doses. If you miss a dose of amoxapine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you take 1 dose daily at bedtime, do not take the missed dose the next morning.

Ask your health care provider any questions you may have about how to use amoxapine.

Important safety information:

  • Amoxapine may cause drowsiness, dizziness, blurred vision, or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use amoxapine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol while you are using amoxapine.
  • Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using amoxapine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Amoxapine may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by amoxapine. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
  • Some patients who take amoxapine may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take amoxapine in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, chewing movements, mouth puckering, puffing of cheeks, tongue sticking out) while taking amoxapine.
  • Do not become overheated in hot weather or while being active; heatstroke may occur.
  • Children, teenagers, and young adults who take amoxapine may be at increased risk for suicidal thoughts or actions. Watch all patients who take amoxapine closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
  • Some people may be at risk for eye problems from amoxapine. Your doctor may want you to have an eye exam to see if you are at risk for these eye problems. Call your doctor right away if you have eye pain, vision changes, or swelling or redness in or around the eye.
  • Tell your doctor or dentist that you take amoxapine before you receive any medical or dental care, emergency care, or surgery.
  • Amoxapine may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to amoxapine. Use a sunscreen or protective clothing if you must be outside for a prolonged period.
  • Use amoxapine with caution in the ELDERLY; they may be more sensitive to the effects of amoxapine.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using amoxapine while you are pregnant. Amoxapine is found in breast milk. If you are or will be breast-feeding while you are using amoxapine, check with your doctor or pharmacist to discuss the risks to your baby.

If you suddenly stop taking amoxapine, you may experience WITHDRAWAL symptoms, including headache, nausea, and tiredness.

Possible side effects of amoxapine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; drowsiness; dry mouth.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning, numbness, or tingling; change in balance; change in sex ability; chest pain or pressure; confusion; fainting; fast or irregular heartbeat; feeling very nervous and excitable; mental, mood, or behavior changes (eg, anxiety, mood swings, agitation, irritability, nervousness, restlessness); new or worsening trouble sleeping; not able to pass urine; one-side weakness; seizures; severe or persistent dizziness or headache; suicidal thinking or behavior; tremor; trouble swallowing; uncontrollable or involuntary muscle movements (eg, loss of balance, twitching of the face or tongue, uncontrollable arm or leg movements); unusual tiredness or weakness; vision or speech changes; worsening of depression.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of amoxapine:

Store amoxapine at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep amoxapine out of the reach of children and away from pets.

General information:

  • If you have any questions about amoxapine, please talk with your doctor, pharmacist, or other health care provider.
  • Amoxapine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take amoxapine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about amoxapine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to amoxapine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using amoxapine.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

Hide
(web1)