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Amoxapine Dosage

Applies to the following strength(s): 25 mg ; 50 mg ; 100 mg ; 150 mg

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Depression

Initial dose: 50 mg orally two or three times a day
Maintenance dose: 100 mg orally two or three times a day
Maximum dose: 600 mg orally per day

Comments:
-Increases above 300 mg per day should be made only if 300 mg per day has been ineffective during at least two weeks.
-Hospitalized patients who have been refractory to antidepressant treatment and who have no history of convulsive seizures may have dosage increased cautiously up to 600 mg per day in divided doses.
-This drug may be given in a single daily dose, not to exceed 300 mg, preferably at bedtime.
-Doses above 300 mg should be given in divided doses.

Use:
-Relief of symptoms of depression in patients with neurotic or reactive depressive disorders as well as endogenous and psychotic depressions

Usual Geriatric Dose for Depression

Initial dose: 25 mg orally two or three times a day
Maintenance dose: 50 mg orally two or three times a day
Maximum dose: 300 mg orally per day

Comments:
-Once an effective dosage is established, this drug may be administered in a single bedtime dose, not to exceed 300 mg.
-Recommended maintenance dosage is the lowest dose that will maintain remission.
-If symptoms reappear, the dosage should be increased to previous level until symptoms are under control.

Use:
-Relief of symptoms of depression in patients with neurotic or reactive depressive disorders as well as endogenous and psychotic depressions

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

BOXED WARNING(S):
Suicidality and Antidepressant Drugs
-Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of this drug or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need.
-Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24. There was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older.
-Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber.
-This drug is not approved for use in pediatric patients.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Monitoring:
-Psychiatric: Patients should be monitored for clinical worsening and emergence of suicidal thoughts.

Patient advice:
-Somnolence has been reported. Caution in driving and operating machinery is recommended until the individual response to the drug has been determined.

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