Skip to main content

TMS Oral Granules (Canada)

This page contains information on TMS Oral Granules for veterinary use.
The information provided typically includes the following:
  • TMS Oral Granules Indications
  • Warnings and cautions for TMS Oral Granules
  • Direction and dosage information for TMS Oral Granules

TMS Oral Granules

This treatment applies to the following species:
Company: Bio Agri Mix

Sulfadiazine and Trimethoprim Oral Granules

For Veterinary Use Only


DIN 02503425


TMS Oral Granules contains trimethoprim, a synthetic antibacterial, and sulfadiazine, a sulfonamide in combination at a ratio of 1:5. The two components of TMS Oral Granules produce a sequential blockade of bacterial metabolism, giving a level of activity many times greater than that obtained from either drug alone.

Dosage Form

TMS Oral Granules is a dosage form containing 6.7% w/w trimethoprim USP and 33.3% w/w sulfadiazine USP in an inert carrier.

Spectrum Of Activity

TMS Oral Granules provides effective antibacterial activity against a wide range of infections caused by Gram-positive and Gram-negative bacteria.

Pathogenic bacteria which can cause infection in the horse and are susceptible to TMS Oral Granules in vitro include:

Very Sensitive Organisms

Escherichia coli

Salmonella spp.

Haemophilus spp.

Shigella equirulis

Pasteurella spp.

Sensitive Organisms

Streptococcus spp.

Klebsiella spp.

Proteus spp.

Bordetella spp.

Listeria monocytogenes

Staphylococcus spp. (including penicillinase-producing staphylococci)

Corynebacterium spp.

Actinobacillus spp.

Non-sensitive Organisms

Pseudomonas aeruginosa

Leptospira spp.

TMS Oral Granules Indications

TMS Oral Granules is indicated in horses for the treatment of the following infections when caused by susceptible organisms:

- Acute strangles

- Other respiratory infections

- Wound and postoperative infections

TMS Oral Granules Dosage And Administration

To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

The usual dose of TMS Oral Granules for horses, ponies and foals is 3.75 g per 50 kg. The content of one scoop (37.5 g) is sufficient to treat 480 kg liveweight. This dose provides 30 mg/kg of actives daily.

The granules should be mixed with a small amount of palatable feed. TMS Oral Granules is palatable but if the treated horse does not consume the medication in total, then parenteral or individual oral dosage with an alternative product should be considered.

Treatment should be given once daily until 2-3 days after the animal becomes asymptomatic. The usual course of treatment is for not longer than 7 consecutive days.


TMS Oral Granules should not be used in horses showing marked liver parenchymal damage or blood dyscrasias, nor in those with a history of sulfonamide sensitivity.

Adverse Reactions

No significant adverse reactions have been reported.

TMS Oral Granules Cautions

TMS Oral Granules should not be administered to pregnant mares as the effects of this product when used as recommended, on the unborn foal have not been determined.


Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug.

Sulfonamides can cause allergic reactions in sensitized individuals. When handling the product, avoid inhalation, oral exposure and direct contact with skin or eyes.

Keep out of reach of children.


Store below 30°C. Protect from light.


20 kg pail, 1 kg jar, 375 g jar.

Manufactured and Distributed by

Bio Agri Mix LP, PO Box 399, Mitchell, ON, N0K 1N0



Net Contents



9636-00, AUG/20

9638-00, AUG/20

1 kg

9637-00, AUG/20

9638-00, AUG/20

20 kg

9621-00, AUG/20

9638-00, AUG/20

CPN: 1161057.1

Telephone:   519-348-9865
Order Desk:   800-265-1763
Technical Information:   226-303-2503
Fax:   519-348-4100
THIS SERVICE AND DATA ARE PROVIDED "AS IS". Animalytix assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the Animalytix service and data. See the Terms of Use for further details.

Copyright © 2023 Animalytix LLC. Updated: 2023-05-29