TMS Oral Granules (Canada)This page contains information on TMS Oral Granules for veterinary use.
The information provided typically includes the following:
- TMS Oral Granules Indications
- Warnings and cautions for TMS Oral Granules
- Direction and dosage information for TMS Oral Granules
TMS Oral GranulesThis treatment applies to the following species:
Sulfadiazine and Trimethoprim Oral Granules
For Veterinary Use Only
TMS Oral Granules contains trimethoprim, a synthetic antibacterial, and sulfadiazine, a sulfonamide in combination at a ratio of 1:5. The two components of TMS Oral Granules produce a sequential blockade of bacterial metabolism, giving a level of activity many times greater than that obtained from either drug alone.
TMS Oral Granules is a dosage form containing 6.7% w/w trimethoprim USP and 33.3% w/w sulfadiazine USP in an inert carrier.
Spectrum Of Activity
TMS Oral Granules provides effective antibacterial activity against a wide range of infections caused by Gram-positive and Gram-negative bacteria.
Pathogenic bacteria which can cause infection in the horse and are susceptible to TMS Oral Granules in vitro include:
Very Sensitive Organisms
Staphylococcus spp. (including penicillinase-producing staphylococci)
TMS Oral Granules Indications
TMS Oral Granules is indicated in horses for the treatment of the following infections when caused by susceptible organisms:
- Acute strangles
- Other respiratory infections
- Wound and postoperative infections
TMS Oral Granules Dosage And Administration
To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.
The usual dose of TMS Oral Granules for horses, ponies and foals is 3.75 g per 50 kg. The content of one scoop (37.5 g) is sufficient to treat 480 kg liveweight. This dose provides 30 mg/kg of actives daily.
The granules should be mixed with a small amount of palatable feed. TMS Oral Granules is palatable but if the treated horse does not consume the medication in total, then parenteral or individual oral dosage with an alternative product should be considered.
Treatment should be given once daily until 2-3 days after the animal becomes asymptomatic. The usual course of treatment is for not longer than 7 consecutive days.
TMS Oral Granules should not be used in horses showing marked liver parenchymal damage or blood dyscrasias, nor in those with a history of sulfonamide sensitivity.
No significant adverse reactions have been reported.
TMS Oral Granules Cautions
TMS Oral Granules should not be administered to pregnant mares as the effects of this product when used as recommended, on the unborn foal have not been determined.
Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug.
Sulfonamides can cause allergic reactions in sensitized individuals. When handling the product, avoid inhalation, oral exposure and direct contact with skin or eyes.
Keep out of reach of children.
Store below 30°C. Protect from light.
20 kg pail, 1 kg jar, 375 g jar.
Manufactured and Distributed by
Bio Agri Mix LP, PO Box 399, Mitchell, ON, N0K 1N0
P.O. BOX 399, 11 ELLENS STREET, MITCHELL, ON, N0K 1N0
Copyright © 2023 Animalytix LLC. Updated: 2023-05-29