Settle
This treatment applies to the following species:MYCOBACTERIUM CELL WALL FRACTION IMMUNOSTIMULANT
For Veterinary Use Only
For intravenous / intrauterine use only
Settle Indications
Recommended as an aid in the treatment of equine endometritis caused by Streptococcus zooepidemicus.
Dosage & Administration: Administer 1.5 mL by intrauterine instillation with a sterile catheter or by intravenous injection into the jugular vein during the early estrus period. Treatment may be repeated at subsequent natural or induced estrus periods.
Intravenous: Administer 1.5 mL of Settle® by intravenous injection into the jugular vein. Use strict aseptic technique.
Intrauterine: Administer 1.5 mL by intrauterine instillation using strict aseptic technique. Dilute 1.5 mL of Settle® in sterile lactated ringers, normal saline, water for injection or semen extender to provide an approximate final volume of 25 - 50 mL. Aseptically administer the diluted solution into the uterus using a sterile catheter.
Precaution: Store at 2° - 7°C. (35° - 45°F). Do not freeze. Mix thoroughly before injecting. Use entire contents when first opened. Contains gentamicin as a preservative. Do not administer within 21 days of slaughter. If anaphylaxis occurs, administer epinephrine. KEEP OUT OF THE REACH OF CHILDREN.
Contraindications
Cortisone reduces the production of interleukin-1 (IL-1). Mares being treated with corticosteroids or ACTH may not respond to Settle® therapy.
Product Description: Settle® is an emulsion of purified mycobacterium cell walls that have been extracted by a process that reduces their toxic and allergic effects. Settle® enhances the innate humoral immune responses by activating macrophages and stimulating the cloning of polymorphonuclear leukocytes (PMN). These activated phagocytic cells stimulate a cytokine cascade that results in the destruction of bacteria, such as Streptococcus zooepidemicus.
Side Effects
Mild fever, drowsiness, and decreased appetite may occur for 1 to 2 days following intravenous injection. These are normal responses to the release of IL-1. An elevated body temperature enhances the immune function by stimulating leukocyte activity and thus is not an adverse side effect.Packaging: Settle® is available in cartons containing 6 x 1.5 mL single-dose vials.
Manufactured by NovaVive USA Inc., 119 Rowe Rd., Athens, Georgia, U.S.A. 30601
U.S. Vet. Lic. No. 289
Toll-free: 1-844-663-3349
Email: info@novavive.ca
Protected by one or more of the following patents:
US: 4744984, 5632995, 5759554, 6139844, 6890541
CA: 1293190, 2154689, 2170142, 2284932, 2284937, 2378888
CPN: 1843003.0
119 ROWE RD., ATHENS, GA, 30601
Toll-Free: | 1-844-663-3349 | |
Website: | www.novavive.ca | |
Email: | info@novavive.ca |
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Copyright © 2025 Animalytix LLC. Updated: 2025-05-29
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