Metricure (Canada)This page contains information on Metricure for veterinary use.
The information provided typically includes the following:
- Metricure Indications
- Warnings and cautions for Metricure
- Direction and dosage information for Metricure
MetricureThis treatment applies to the following species:
CEPHAPIRIN BENZATHINE UTERINE SUSPENSION
FOR VETERINARY USE ONLY
Each 19 gram syringe contains:
640 mg cephapirin benzathine
0.09 g cetomacrogol 1000 (emulsifier)
0.21 g eumulgin B1 (emulsifier)
0.15 g hydrogenated castor oil (stabilizer)
in fractionated coconut oil (vehicle)
Metricure is an antibiotic indicated for the treatment of subacute and chronic endometritis in cows caused by Actinomyces (Corynebacterium) pyogenes, Fusobacterium necrophorum and pigment-forming Bacteroides strains.
To accurately diagnose subacute or chronic endometritis, a vaginoscopic examination should be done to confirm the presence of a discharge from the cervix.
DOSAGE AND ADMINISTRATION
Thoroughly clean the vulvar area, maintain aseptic conditions and avoid contaminating the catheter in preparation for the infusion.
Introduce a single dose of 640 mg of cephapirin benzathine (one 19 g syringe) into the lumen of the uterus using a disposable catheter. Fix the syringe to the catheter, then taking the cervix into a gloved hand introduced into the rectum; introduce the catheter through the cervix into the lumen of the uterus by gentle oscillating movements of the cervix. Inject the contents of the syringe.
One treatment is usually sufficient for a complete cure. If the quantity and quality of the cervical discharge is not improved at examination 14 days after treatment, the cow should receive a second treatment. Other contaminating organisms not sensitive to cephapirin may be the cause of the infection and accurate laboratory diagnosis may be necessary. In inseminated animals, Metricure can be used one day following insemination.
Use of the product should be based on susceptibility testing of the bacteria isolated from the animal. If this is not possible, therapy should be based on local (regional, farm level) epidemiological information about susceptibility of the target bacteria.
In case of anaphylactic reaction administer epinephrine.
Treated animals must not be slaughtered for use in food for at least 48 hours after the latest treatment with this drug.
No milk withholding time is required when used according to the label.
Cephalosporins can cause allergic reactions in sensitized individuals. When handling the product, avoid oral exposure and direct contact with skin or eyes.
Keep out of reach of children.
Allergic reactions have been observed in very rare cases.
Cephapirin, a first generation cephalosporin, is a broad spectrum antibiotic with bactericidal action against sensitive gram-positive bacteria and gram-negative anaerobic bacteria. It is resistant to the action of penicillinase and is active in an anaerobic environment as encountered in an infected uterus. After a single treatment with Metricure, concentrations of cephapirin in endometrial tissue above the MIC of sensitive bacteria are maintained for at least 24 hours.
The suspension is easily infused and is well tolerated, enabling good diffusion of cephapirin into the endometrium.
Store in a dry place between 15° and 25°C.
Box of 10 x 19 g syringes, 10 catheters and 10 gloves.
Box of 12 x 19 g syringes.
Intervet Canada Corp, 16750, route Transcanadienne, Kirkland QC, H9H 4M7
® Intervet International B.V. Used under license.
Intervet Canada Corp. is a subsidiary of Merck & Co., Inc.
Version 16 August 2017
Intervet Canada Corp.
16750 ROUTE TRANSCANADIENNE, KIRKLAND, QC, H9H 4M7
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