Fertiline (Canada)This page contains information on Fertiline for veterinary use.
The information provided typically includes the following:
- Fertiline Indications
- Warnings and cautions for Fertiline
- Direction and dosage information for Fertiline
FertilineThis treatment applies to the following species:
Gonadorelin Acetate Sterile Injectable Solution
Synthetic Hypothalamic Luteinizing Hormone-Releasing Hormone (LHRH)
FERTILINE is the trade name registered by IAF BioChem International Inc. for the structural synthetic decapeptide (pyro) Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. This sequential structure is physiologically and chemically identical to the neuro-hormone secreted by the hypothalamus of many animal species; it is designated under various names: Gonadorelin, LHRH, GnRH, GnRF, LRF.
The sterile solution contains 50 micrograms per millilitre (50 µg/mL).
50 micrograms per millitre (50 µg/mL)
Preservative: Benzyl Alcohol
FERTILINE is recommended as an aid in reproductive management in cattle and is used mainly for the treatment of cystic ovaries in the bovine.
Pharmacology And Toxicology
During the normal oestrus cycle of mammals two gonadotrophins FSH (follicle-stimulating hormone) and LH (luteinizing hormone) act specifically on the ovaries. These two hormones are released by the anterior hypophysis following stimulation by neurohormones secreted by the hypothalamus. The production and release of these hormones is modulated by a feedback mechanism operating between the hypothalamus and pituitary.
The hypothalamic hormones are peptides.
When administered intramuscularly, the synthetic hypothalamic luteinizing hormone-releasing hormone has an effect similar to the purified natural hormone: it increases the anterior hypophyseal secretion of gonadotrophins, specifically LH and FSH. It improves the overall conception rate by enhancing normal hypothalamopituitary function, thus reestablishing the normal growth and maturation of follicles.
Administered intramuscularly to cows at doses up to 400 µg, gonadorelin acetate is not toxic, does not produce any untoward reactions and does not alter the haematological or biochemical blood parameters. At the recommended levels this hormone has no embryotoxic or teratogenic effects.
Fertiline Dosage And Administration
The recommended intramuscular dose of FERTILINE is 100 µg per cow (2 mL of a solution containing 50 µg/mL).
Store at controlled room temperature (15°C - 25°C), in the dark.
No meat withdrawal period and no milk withholding time are required when used according to the label. Keep out of reach of children.
FERTILINE in multidose vials of 20 mL and 50 mL of a sterile solution containing 50 µg/mL of gonadorelin acetate.
VETERINARY USE ONLY
Vetoquinol N.-A. Inc., 2000, ch. Georges, Lavaltrie, QC, Canada J5T 3S5
2000, CHEMIN GEORGES, LAVALTRIE, QC, J5T 3S5
|Every effort has been made to ensure the accuracy of the Fertiline information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.|
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