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Fertiline (Canada)

This page contains information on Fertiline for veterinary use.
The information provided typically includes the following:
  • Fertiline Indications
  • Warnings and cautions for Fertiline
  • Direction and dosage information for Fertiline

Fertiline

This treatment applies to the following species:
Manufacturer: Vétoquinol

Gonadorelin Acetate Sterile Injectable Solution

Synthetic Hypothalamic Luteinizing Hormone-releasing Hormone (LHRH)

DIN: 02030314

Description

FERTILINE is the trade name registered by IAF BioChem International Inc. for the structural synthetic decapeptide (pyro) Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. This sequential structure is physiologically and chemically identical to the neuro-hormone secreted by the hypothalamus of many animal species; it is designated under various names: Gonadorelin, LHRH, GnRH, GnRF, LRF.

The sterile solution contains 50 micrograms per milliliter (50 μg/mL).

Active Ingredients

Gonadorelin Acetate

50 micrograms per milliliter (50 µg/mL).


Preservative: Benzyl Alcohol

2% V/V

I.M.

Fertiline Indications

FERTILINE is recommended as an aid in reproductive management in cattle and is used mainly for treatment of cystic ovaries in the bovine.

Pharmacology And Toxicology

During the normal oestrus cycle of mammals two gonadotrophins FSH (follicle-stimulating-hormone) and LH (luteinizing hormone) act specifically on the ovaries. These two hormones are released by the anterior hypophysis following stimulation by neurohormones secreted by the hypothalamus. The production and release of these hormones is modulated by a feedback mechanism operating between the hypothalamus and pituitary. The hypothalamic hormones are peptides.

When administered intramuscularly, the synthetic hypothalamic luteinizing hormone-releasing hormone has an effect similar to the purified natural hormone: it increases the anterior hypophyseal secretion of gonadotrophins, specifically LH and FSH. It improves the overall conception rate by enhancing normal hypothalamo-pituitary function, thus re-establishing the normal growth and maturation of follicles.

Administered intramuscularly to cows at doses up to 400 µg, gonadorelin acetate is not toxic, does not produce any untoward reactions and does not alter the haematological or biochemical blood parameters. At the recommended levels this hormone has no embryotoxic or teratogenic effects.

Fertiline Dosage And Administration

The recommended intramuscular dose of FERTILINE is 100 µg per cow (2 mL of a solution containing 50 µg/mL).

Storage

Store at controlled room temperature (15°C - 25°C), in the dark.

Warnings

Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug.

Availability

FERTILINE in multidose vials of 20 mL and 50 mL of a sterile solution containing 50 µg/mL of gonadorelin acetate.

Vétoquinol N.-A. Inc., 2000, ch. Georges, Lavaltrie, QC, Canada J5T 3S5

FOR VETERINARY USE ONLY

432479 0712 B

Net

Code:

20 mL

040502634

50 mL

026106

NAC No.: 12340337

VETOQUINOL N.-A. INC.
Commercial Division

2000, CHEMIN GEORGES, LAVALTRIE, QC, J5T 3S5
Telephone:   450-586-2252
Order Desk:   800-363-1700
Fax:   450-586-4649
Website:   www.vetoquinol.ca
Email:   info@vetoquinol.ca
Every effort has been made to ensure the accuracy of the Fertiline information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2016 North American Compendiums. Updated: 2016-08-21

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