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Borgal (Canada)

This page contains information on Borgal for veterinary use.
The information provided typically includes the following:
  • Borgal Indications
  • Warnings and cautions for Borgal
  • Direction and dosage information for Borgal


This treatment applies to the following species:
Company: Merck Animal Health

Trimethoprim and sulfadoxine injectable solution

DIN: 00555657




Each mL contains:

Active ingredients:

trimethoprime Ph. Eur.

40 mg

sulfadoxine Ph. Eur.

200 mg

Non-medicinal ingredients:

sodium hydroxide Ph. Eur.

25.775 mg

glycerinformal Mfr. Std.

766.50 mg

water for injection Ph. Eur.

203.725 mg

BORGAL contains trimethoprim (a synthetic antibacterial), and sulfadoxine (a sulfonamide). The two components of BORGAL produce a sequential double blockade of bacterial metabolism, giving a level of activity many times greater than that obtained from either drug alone.

BORGAL provides effective antibacterial activity against a wide range of infections caused by Gram-positive and Gram-negative bacteria.

BORGAL has shown activity in vitro against the following organisms:

Very Sensitive Organisms

Escherichia coli

Bacillus anthracis

Clostridium spp.

Pasteurella spp.

Shigella spp.

Haemophilus influenzae

Streptococcus zooepidemicus

Salmonella spp.

Proteus mirabilis

Vibrio spp.

Sensitive Organisms

Streptococcus viridans

Proteus spp.

Brucella spp.


Enterococci spp.

Corynebacterium spp.

Staphylococcus aureus including penicillinase-producing organisms

Bordetella spp.

Neisseria spp.

Klebsiella spp.

Moderately Sensitive Organisms

Enterobacter aerogenes

Nocardia spp.

Non-sensitive Organisms

Pseudomonas aeruginosa*

Leptospira spp.

Mycobacterium tuberculosis

Erysipelothrix rhusiopathiae

*usually non-sensitive

Borgal Indications

BORGAL may be used in cattle and swine where potent antibacterial action against a wide range of infections caused by sensitive organisms is required.

BORGAL is indicated in cattle for the treatment of:

RESPIRATORY TRACT INFECTIONS - bacterial pneumonias including bovine pneumonic pasteurellosis (shipping fever).

ALIMENTARY TRACT INFECTIONS - primarily enteric and septicaemic colibacillosis and salmonellosis.

OTHER INFECTIONS - infectious pododermatitis (foot rot) and septicaemias.

BORGAL is indicated in swine for the treatment of:

RESPIRATORY TRACT INFECTIONS - bacterial pneumonias.

ALIMENTARY TRACT INFECTIONS - colibacillosis and post-weaning scours.

OTHER INFECTIONS - mastitis-metritis-agalactia syndrome of sows (MMA) and bacterial arthritis.

Borgal Dosage And Administration

BORGAL should be administered at a dose rate of 16 mg/kg body weight (3 mL per 45 kg [100 lb]) daily. In piglets weighing less than 4.5 kg (10 lb) do not exceed a dose of 0.5 mL.

Intramuscular injection is recommended for cattle and swine, but if a particularly rapid response is required in acute infections, BORGAL can be administered by slow intravenous injection.

Treatment should continue for 2-3 days after symptoms have subsided. The usual course of treatment is for not longer than 5 consecutive days.


BORGAL should not be used in cattle or swine showing marked liver parenchymal damage or blood dyscrasias, nor in those with a history of sulfonamide sensitivity.

Borgal Cautions

With intravenous therapy generally, and sulfonamides in particular, hypersensitivity reactions can occur and should be appropriately treated with corticosteroids or epinephrine.

Temporary, local, irritating swellings are encountered occasionally after intramuscular injection of BORGAL.


Milk taken from treated animals during treatment and within 96 hours after the latest treatment with this drug must not be used as food. Treated animals must not be slaughtered for use in food for at least 10 days after the latest treatment with this drug. Keep out of reach of children.

Adverse Reactions

No significant adverse reactions have been reported.


Store at room temperature, below 25°C.


Bottles of 100 mL, 250 mL and 500 mL

Intervet Canada Corp., 16750, route Transcanadienne, Kirkland QC, H9H 4M7


Intervet Canada Corp. is a subsidiary of Merck & Co., Inc

Version 02 February 2012

® Registered trademark of Intervet International B.V. Used under license.

CPN: 12081283

Intervet Canada Corp.

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