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Active substance(s): ACETAZOLAMIDE

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Patient Information Leaflet

Diamox® 250 mg Tablets
Read all of this leaflet carefully before you start taking this
Keep this leaflet. You may need to read it again. If you have any
further questions, ask your doctor or pharmacist. This medicine has
been prescribed for you. Do not pass it on to others. It may harm them,
even if their symptoms are the same as yours. If any of the side effects
become serious, or if you notice any side effects not listed in this
leaflet, please tell your doctor or pharmacist.
In this leaflet:
1. What Diamox 250mg Tablets are and what they are used for
2. Before you take Diamox 250mg Tablets
3. How to take Diamox 250mg Tablets
4. Possible side effects
5. How to store Diamox 250mg Tablets
6. Further information
1. What Diamox 250mg Tablets are and what they are used for
Diamox® 250 mg Tablets (referred to as Diamox 250mg Tablets
throughout this leaflet) contain the active substance Acetazolamide.
This belongs to a group of medicines known as carbonic anhydrase
Diamox 250mg Tablets are used to treat:
• glaucoma (a condition of the eye), by reducing the pressure within
the eye
• abnormal retention of fluids (Diamox 250mg Tablets acts as a
• epilepsy (fits or convulsions).
2. Before you take Diamox 250mg Tablets
DO NOT take Diamox 250mg Tablets if:
• you know you are allergic to sulphonamides, sulphonamide
derivatives including acetazolamide or to any of the ingredients in
the medicine (listed in Section 6 at the end of this leaflet)
• you have severe liver problems
• you have or have ever had severe kidney problems
• you have a particular type of glaucoma known as chronic non
congestive angle closure glaucoma (your doctor will be able to
advise you)
• you have reduced function of the adrenal glands – glands above
the kidneys – (also known as Addison’s disease)
• you have low blood levels of sodium and/or potassium or high
blood levels of chlorine (your doctor will advise you).
Speak to your doctor if any of the above applies to you.
Take special care and speak to your doctor before taking Diamox
250mg Tablets if:
• you have or have ever had kidney problems such as kidney stones
• you have lung problems such as chronic bronchitis or emphysema,
which cause difficulty in breathing
• you are over the age of 65
• a small number of people being treated with anti-epileptics such as
Acetazolamide have had thoughts of harming or killing themselves,
if at any time you have these thoughts, immediately contact your
Diamox 250mg Tablets may affect some medical tests. If you visit a
hospital or clinic for any medical tests, you should tell the doctor
concerned that you are taking Diamox 250mg Tablets.

Taking other medicines:
Please tell your doctor or pharmacist if you are taking or have recently
taken any other medicines, including medicines obtained
without a prescription. The effects of any of these medicines may
change, particularly if you are taking, or using, any of the following:
• medicines for your heart such as cardiac glycosides (e.g. digoxin)
• medicines to reduce blood pressure
• medicines to thin your blood (e.g. warfarin)
• medicines to lower the sugar in your blood (e.g. metformin,
• medicines for epilepsy or fits (in particular, phenytoin, primidone or
carbamazepine or topiramate)
• drugs which interfere with folic acid, e.g. methotrexate,
pyrimethamine, or trimethoprim
• steroids such as prednisolone
• aspirin and related medicines, e.g. salicylic acid or choline
salicylate for mouth ulcers
• other drugs in the group of medicines called carbonic anhydrase
inhibitors (e.g. dorzolamide or brinzolamide which are also used to
treat glaucoma)
• amphetamines (a stimulant), quinidine (treats an irregular heart
beat), methenamine (prevents urine infections) or lithium (treats
severe mental problems)
• sodium bicarbonate therapy (used to treat high states of acid in
your body)
• ciclosporin (used to suppress the immune system).
Pregnancy and breast feeding:
Ask your doctor or pharmacist for advice before taking any medicines.
Diamox 250mg Tablets SHOULD NOT be taken if you are pregnant,
think you are pregnant or are planning to become pregnant.
It may be taken when breast feeding but only on the advice of the
Driving and using machines:
If Diamox 250mg Tablets make you feel drowsy or confused you
should not drive or operate machines. Diamox 250mg Tablets can
occasionally cause short-sightedness; if this happens and you feel that
you can no longer drive safely, you should stop driving and contact
your doctor.
3. How to take Diamox 250mg Tablets
• Always take the number of tablets your doctor has told you to take.
This information will also be on the label.
• Diamox 250mg Tablets should be swallowed whole with a drink of
water, just before or just after a meal. Do not chew or crush the
• The dose varies from person to person depending on their
condition. Your doctor will decide on the most appropriate dose. If
you are not sure how many tablets to take or when to take them,
ask your doctor or pharmacist.
Adults: 250mg-1000mg (1-4 tablets) every 24 hours, in divided doses.
Retention of fluid:
Adults: starting dose is 250-375mg (1-1.5 tablets) once daily in the
morning. Your doctor will adjust the dose and tell you how often to take
your dose.
Adults: 250-1000mg daily in divided doses.
Children: the dose will depend on the bodyweight of the child, to be
taken in divided doses. Dose should not be more than 750mg (3
tablets) per day.
• Before starting and during treatment your doctor may monitor your
blood to check that treatment with Diamox 250mg Tablets is
suitable for you.

If you take more Diamox 250mg Tablets than you should:
Get medical help immediately, either by calling your doctor or going to
the nearest hospital casualty department. Take any remaining tablets
and this leaflet with you so that the medical staff know exactly what
you have taken.
If you forget to take your Diamox 250mg Tablets:
You should take it as soon as you remember. However, if this is within
two hours of your next dose you should skip the missed tablets and
carry on taking the rest of your tablets as usual.
DO NOT take a double dose of tablets to make up the missed dose.
If you have any further questions about these tablets, ask your
doctor or pharmacist.
4. Possible side effects
Like all medicines, Diamox 250mg Tablets can cause side effects,
although not everybody gets them.
All medicines can cause allergic reactions although serious
allergic reactions are very rare. Any sudden wheeziness, difficulty
in breathing, swelling of the eyelids, face or lips, rash or itching
(especially affecting your whole body) should be reported to a
doctor immediately.
Extremely rarely, Diamox 250mg Tablets can affect the cells in your
blood. This could mean that you are more likely to catch
infections and that your blood may not clot properly. If you have a sore
throat or fever or you notice bruises or tiny red or purple spots on your
skin you should contact your doctor immediately. If your muscles feel
weak or you have fits, you should see your doctor immediately.
Very rarely, Diamox 250mg Tablets can affect the liver and kidneys. If
you experience pain in your lower back, pain or burning
when you pass urine, have difficulty in passing urine, or you stop
passing urine, have blood in your urine, pale stools, or if your
skin or eyes look slightly yellow, you should contact your doctor. You
should also contact your doctor if your stools are black or tarry, or if
you notice blood in your stools.
Common side effects are:
• headache
• diarrhoea
• feeling or being sick, loss of appetite, thirst, or a metallic taste in
the mouth
• dizziness, loss of full control of arms or legs
• looking flushed
• a need to pass urine more often than normal
• tiredness or irritability
• feeling over-excited
• a tingling or numbness in the fingers or toes, or coldness in the
Uncommon side effects are:
• depression
• drowsiness or confusion
• a loss of interest in sex
• ringing in the ears or difficulty in hearing
• temporary short-sightedness which subsides when the dosage is
reduced or treatment is stopped.
Rare cases of skin rashes including an increased sensitivity to sunlight
have been reported. If you experience any unusual skin rashes, inform
your doctor.
If you take Diamox 250mg Tablets for a long time it can occasionally
affect the amount of potassium, or sodium in your blood.
Your doctor will probably take blood tests to check that this does not
happen. You might also experience bone thinning or the risk of kidney
stones with long-term therapy. High or low blood sugar levels may
occasionally occur.

If any of the side effects becomes serious, or if you notice any
side effects not listed in this leaflet, please tell your doctor or
Reporting of side effects:
If you get any side effects, talk to your doctor, pharmacist or nurse.
This includes any possible side effects not listed in this leaflet. You can
also report side effects directly via the Yellow Card Scheme at:
By reporting side effects you can help provide more information on the
safety of this medicine
5. How to store Diamox 250mg tablets
Keep out of the sight and reach of children.
Do not store above 25°C.
Store in the original package in order to protect from light and
Do not use after the expiry date printed on the pack. The expiry date
refers to the last day of that month.
Medicines should not be disposed of via wastewater or household
waste. Ask your pharmacist how to dispose of medicines no longer
required. These measures will help to protect the environment.
If your tablets become discoloured or show any signs of deterioration,
seek the advice of your pharmacist.
This medicine is for you. Only a doctor can prescribe it for you.
Never give this medicine to someone else; it could harm them,
even if their symptoms seem the same as yours.
6. Further Information
What Diamox 250mg Tablets contain:
The active substance is acetazolamide.
Each tablet contains 250mg acetazolamide
The other ingredients are: calcium hydrogen phosphate, sodium starch
glycolate, corn starch, magnesium stearate, povidone and sodium salt.
What Diamox 250mg Tablets look like and contents of the pack:
Diomex 250mg Tablets are round, white tablets engraved with
‘FW 147’ on one side and scored in quarters on the other.
They are supplied in blister packs of 100 and 120 tablets.
Manufacturer: Custom Pharmaceuticals Limited,
Conway Street, Hove, East Sussex, BN3 3LW, UK.
Procured within the EU.


Product Licence holder: Ecosse Pharmaceuticals Limited,
3 Young Place, East Kilbride G75 0TD, UK.
Re-packaged by: Munro Wholesale Medical Supplies Limited,
3 Young Place, East Kilbride G75 0TD, UK.
PL 19065/0501
This leaflet was revised 27/04/2017

If you are blind or partially sighted
and require this leaflet in a different
format, call 01355 574450 and ask
for the Regulatory Department.
Diamox® is a registered trade mark of Wyeth Holdings LLC

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.