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Tecartus

Generic Name: brexucabtagene autoleucel
Dosage Form: suspension for intravenous infusion

Medically reviewed by Judith Stewart, BPharm. Last updated on Jul 28, 2020.

What is Tecartus?

Tecartus is a treatment for your mantle cell lymphoma. It is used following disease progression while on or after other treatment. Tecartus is different than other cancer medicines because it is made from your own white blood cells, which have been modified to recognize and attack your lymphoma cells.

Important information

Tecartus may cause side effects that are life-threatening and can lead to death. Call or see your doctor or get emergency help right away if you get any of the following:

  • Fever (100.4°F/38°C or higher)
  • Difficulty breathing
  • Chills or shaking chills
  • Confusion
  • Dizziness or lightheadedness
  • Severe nausea, vomiting, or diarrhea
  • Fast or irregular heartbeat
  • Severe fatigue or weakness

It is important to tell your healthcare provider that you received Tecartus and to show them your Tecartus Patient Wallet Card. Your healthcare provider may give you other medicines to treat your side effects.

Before you receive Tecartus

Before getting Tecartus, tell your healthcare provider about all your medical problems, including if you have or have had:

  • Neurologic problems (such as seizures, stroke, or memory loss)
  • Lung or breathing problems
  • Heart problems
  • Liver problems
  • Kidney problems
  • A recent or active infection

Tell your healthcare provider about all the medications you take, including prescription and overthe-counter medicines, vitamins, and herbal supplements.

How will I receive Tecartus?

  • Since Tecartus is made from your own white blood cells, your blood will be collected by a process called “leukapheresis”, which will concentrate your white blood cells.
  • Your blood cells will be sent to a manufacturing center to make your Tecartus.
  • Before you get Tecartus, you will get three days of chemotherapy to prepare your body.
  • When your Tecartus is ready, your healthcare provider will give it to you through a catheter placed into your vein (intravenous infusion). The infusion usually takes less than 30 minutes.
  • You will be monitored where you received your treatment daily for at least seven days after the infusion.
  • You should plan to stay close to the location where you received your treatment for at least four weeks after getting Tecartus. Your healthcare provider will help you with any side effects that may occur.
  • You may be hospitalized for side effects. Your healthcare provider will discharge you if your side effects are under control and it is safe for you to leave the hospital.
  • Your healthcare provider will want to do blood tests to follow your progress. It is important that you do have your blood tested. If you miss an appointment, call your healthcare provider as soon as possible to reschedule.

What should I avoid after receiving Tecartus?

  • Do not drive, operate heavy machinery, or do other dangerous things for eight weeks after you get Tecartus because the treatment can cause sleepiness, confusion, weakness, and temporary memory and coordination problems.
  • Do not donate blood, organs, tissues, or cells for transplantation.

Tecartus side effects

The most common side effects include:

  • Fever (100.4°F/38°C or higher)
  • Low white blood cells (can occur with a fever)
  • Low red blood cells
  • Low blood pressure (dizziness or lightheadedness, headache, feeling tired, short of breath)
  • Fast heartbeat
  • Confusion
  • Difficulty speaking or slurred speech
  • Nausea
  • Diarrhea

These are not all the possible side effects. Call your healthcare provider about any side effects that concern you. You may report side effects to the FDA at 1-800-FDA-1088.

General information about the safe and effective use of Tecartus

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider for information that is written for health professionals.

What are the ingredients in Tecartus?

Active ingredients: brexucabtagene autoleucel.
Inactive ingredients: albumin (human); DMSO.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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