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Zimhi Side Effects

Generic name: naloxone

Medically reviewed by Drugs.com. Last updated on Mar 1, 2024.

Note: This document provides detailed information about Zimhi Side Effects associated with naloxone. Some dosage forms listed on this page may not apply specifically to the brand name Zimhi.

Applies to naloxone: injection solution.

Other dosage forms:

Serious side effects of Zimhi

Along with its needed effects, naloxone (the active ingredient contained in Zimhi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking naloxone:

Incidence not known

  • agitation
  • body aches
  • chest pain
  • coughing that sometimes produces a pink frothy sputum
  • crying more than the usual (in babies)
  • diarrhea
  • difficult or trouble breathing
  • excessive crying
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • goosebumps
  • increased or excessive unconscious or jerking movements
  • irregular, fast or slow, or shallow breathing
  • irritability
  • nausea or vomiting
  • nervousness
  • pale or blue lips, fingernails, or skin
  • restlessness
  • runny nose
  • seizures
  • shivering
  • sneezing
  • sweating
  • swelling in the legs and ankles
  • trembling
  • weakness
  • yawning

For healthcare professionals

Applies to naloxone: compounding powder, injectable kit, injectable solution, nasal spray, oral solution.

General

This drug may precipitate abrupt opioid withdrawal in physically dependent persons; signs and symptoms may include body aches, fever, sweating, sneezing, yawning, nausea, vomiting, sweating, lacrimation, rhinorrhea, cramping, insomnia, chills/hot flashes, piloerection, tachycardia, anxiety, restlessness, irritability, tremulousness, hypertension, seizures, and cardiac arrest. In the neonate, opioid withdrawal may also include convulsions, excessive crying, and hyperactive reflexes.[Ref]

Cardiovascular

In postoperative patients, many of whom had cardiovascular disease, the following cardiovascular side effects have been reported: hypotension, hypertension, atrial and ventricular tachycardia, ventricular fibrillation, left ventricular failure, and cardiac arrest. Death, coma, and encephalopathy have been reported as sequelae of these events.[Ref]

Nervous system

Death, coma, and encephalopathy have been reported as a result of abrupt postoperative reversal of opioid depression, primarily in patients with preexisting cardiovascular disorders or in those who received other drugs with similar adverse cardiovascular effects.[Ref]

Respiratory

It has been suggested that pulmonary edema may be due to a centrally mediated massive catecholamine response leading to a dramatic shift of blood volume into the pulmonary vascular bed resulting in increased hydrostatic pressures.

Nasal dryness, nasal edema, nasal congestion, and nasal inflammation were the most common adverse reactions reported in clinical trials with naloxone nasal spray.[Ref]

Local

Gastrointestinal

Dermatologic

Hypersensitivity

Psychiatric

Musculoskeletal

Musculoskeletal pain was one of the more commonly reported adverse reactions in clinical trials with naloxone nasal spray.[Ref]

References

1. (2001) "Product Information. Narcan (naloxone)." DuPont Pharmaceuticals

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

Frequently asked questions

Further information

Zimhi side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.