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Xyralid Side Effects

Generic Name: hydrocortisone / lidocaine topical

Note: This page contains side effects data for the generic drug hydrocortisone / lidocaine topical. It is possible that some of the dosage forms included below may not apply to the brand name Xyralid.

For the Consumer

Applies to hydrocortisone / lidocaine topical: cream, gel/jelly, lotion, pad

As well as its needed effects, hydrocortisone / lidocaine topical may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking hydrocortisone / lidocaine topical, check with your doctor immediately:

Incidence not known:
  • Burning or stinging sensation of the skin
  • paleness or redness of the skin
  • swelling of the skin

For Healthcare Professionals

Applies to hydrocortisone / lidocaine topical: rectal cream, rectal cream with applicator, rectal gel with applicator, rectal kit, rectal pad, topical cream, topical kit, topical lotion, topical pad


Local side effects have included erythema, edema, transient stinging, burning, transient blanching, and locus of abnormal sensation.

Local side effects associated with topical hydrocortisone have included burning, itching, or irritation, especially if applied to denuded skin or with occlusive dressings. Long-term use of topical corticosteroids may result in skin atrophy and thinning, and the development of striae, telangiectasia, subcutaneous hemorrhage, and easy bruising and bleeding. Allergic contact dermatitis is occasionally reported.[Ref]


Endocrine side effects of topical corticosteroids are rare. Glucose intolerance and hyperglycemia may be induced by corticosteroids. These drugs can rarely suppress the hypothalamic-pituitary-adrenal axis. This suppression is more likely when higher potency topical steroids are used over extensive areas and when occlusive dressings are used.[Ref]


1. "Product Information. Lida Mantle HC (hydrocortisone-lidocaine topical)." Bradley Pharmaceuticals Inc, Fairfield, NJ.

2. "Product Information. Peranex HC (hydrocortisone-lidocaine topical)." Bradley Pharmaceuticals Inc, Fairfield, NJ.

It is possible that some side effects of Xyralid may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

More about Xyralid (hydrocortisone / lidocaine topical)

Consumer resources

Other brands: AnaMantle HC, Lidocort, Peranex HC, Ana-Lex, More... (4)

Professional resources

Other Formulations

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