Vutrisiran Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 30, 2023.

Applies to vutrisiran: subcutaneous solution.

Serious side effects of vutrisiran

Along with its needed effects, vutrisiran may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking vutrisiran:

More common side effects

• blurred or change in vision
• chest tightness
• difficulty with reading
• muscle pain or stiffness
• night blindness
• pain in the arms, legs, or joints
• trouble breathing

Less common side effects

• chest pain
• dizziness
• fainting
• pounding, slow heartbeat
• unusual tiredness or weakness

Other side effects of vutrisiran

Some side effects of vutrisiran may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For healthcare professionals

Applies to vutrisiran: subcutaneous solution.

General adverse events

The most common adverse reactions were arthralgia, dyspnea, decrease in vitamin A levels, and pain in extremity.^[Ref]

Cardiovascular

• Common (1% to 10%): Atrioventricular heart block^[Ref]

Local

• Common (defined as at least 5% of the patients): Injection site reactions (bruising, erythema, pruritus, warmth)^[Ref]

Metabolic

• Common (defined as at least 5% of the patients): Decreased vitamin A, increased blood alkaline phosphatase^[Ref]

Musculoskeletal

• Very common (10% or more): Arthralgia (11%)^[Ref]

Other

• Very common (10% or more): Pain in extremity (15%)^[Ref]

Respiratory

• Common (defined as at least 5% of the patients): Dyspnea^[Ref]

Further information

Vutrisiran side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer