Skip to main content

Vutrisiran Dosage

Medically reviewed by Drugs.com. Last updated on Feb 13, 2025.

Applies to the following strengths: 25 mg/0.5 mL

Usual Adult Dose for Amyloidogenic Transthyretin Amyloidosis

Recommended dose: 25 mg administered by subcutaneous injection once every 3 months

Uses: Treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR-PN) and cardiomyopathy of wild-type or hATTR in adults to reduce cardiovascular mortality, cardiovascular hospitalizations and urgent heart failure visits in adults.

Renal Dose Adjustments

Mild and Moderate Renal Dysfunction: No adjustment recommended.
Severe Renal Dysfunction and End-Stage Renal Disease: Data not available

Liver Dose Adjustments

Mild Liver Dysfunction: No adjustment recommended.
Moderate and Severe Liver Dysfunction: Data not available

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

General: To report suspected adverse reactions, contact the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Monitoring:

Patient advice:

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.