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VPRIV Side Effects

Generic Name: velaglucerase alfa

Note: This page contains side effects data for the generic drug velaglucerase alfa. It is possible that some of the dosage forms included below may not apply to the brand name VPRIV.

For the Consumer

Applies to velaglucerase alfa: intravenous powder for solution

As well as its needed effects, velaglucerase alfa (the active ingredient contained in VPRIV) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking velaglucerase alfa, check with your doctor or nurse immediately:

More common:
  • Body aches or pain
  • cough
  • difficulty with breathing
  • dizziness
  • ear congestion
  • facial swelling
  • fever or chills
  • headache
  • loss of voice
  • nasal congestion
  • nausea or vomiting
  • runny nose
  • shortness of breath
  • skin rash
  • sneezing
  • sore throat
  • unusual tiredness or weakness
Less common:
  • Blurred vision
  • bone pain
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • nervousness
  • pain, itching, burning, swelling, or a lump under your skin where the needle is placed
  • pounding in the ears
  • slow or fast heartbeat
  • sweating

Minor Side Effects

Some velaglucerase alfa side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Abdominal or stomach pain
  • back pain
  • joint pain
  • lack or loss of strength
Less common:
  • Feeling of warmth
  • hives or welts
  • itching
  • redness of the skin
  • redness of the face, neck, arms, and occasionally, upper chest

For Healthcare Professionals

Applies to velaglucerase alfa: intravenous powder for injection


The most common side effects were hypersensitivity/infusion-related reactions. The most serious side effects reported were hypersensitivity reactions.[Ref]


The term "hypersensitivity reaction" included any event related to and occurring within up to 24 hours of drug infusion, including at least 1 case of anaphylaxis.

The most common symptoms of hypersensitivity reactions were headache, dizziness, hypotension, hypertension, nausea, fatigue/asthenia, and pyrexia; reactions were generally mild. In therapy-naive patients, onset was usually during the first 6 months of therapy and occurred less often over time.[Ref]

Very common (10% or more): Hypersensitivity reaction (up to 52%)
Frequency not reported: Anaphylaxis, anaphylactoid reaction[Ref]

Nervous system

Very common (10% or more): Headache (up to 35%), dizziness (up to 22%)
Frequency not reported: Paresthesia[Ref]


Very common (10% or more): Pyrexia/increased body temperature (up to 22%), asthenia/fatigue (13%), infusion-related reaction
Common (1% to 10%): Flushing
Frequency not reported: Peripheral edema, influenza-like illness[Ref]


Very common (10% or more): Abdominal pain (up to 19%)
Common (1% to 10%): Nausea, upper abdominal pain
Frequency not reported: Diarrhea, vomiting[Ref]


Very common (10% or more): Back pain (up to 18%), knee joint pain (up to 15%), arthralgia, bone pain
Frequency not reported: Muscle spasm, myalgia, neck pain[Ref]


Very common (10% or more): Prolonged activated partial thromboplastin time (up to 11%)[Ref]


Common (1% to 10%): Tachycardia, hypertension, hypotension[Ref]


Common (1% to 10%): Rash, urticaria
Frequency not reported: Allergic dermatitis, tinea versicolor, pruritus[Ref]


Common (1% to 10%): IgG antibodies to velaglucerase alfa (the active ingredient contained in VPRIV) positive for neutralizing antibody[Ref]


Frequency not reported: Influenza, nasopharyngitis, rhinitis, bronchitis, cough, epistaxis


Frequency not reported: Cystitis, urinary tract infection


1. "Product Information. VPRIV (velaglucerase alfa)." Shire US Inc, Florence, KY.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

It is possible that some side effects of VPRIV may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.