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Valstar Side Effects

Generic Name: valrubicin

Note: This page contains side effects data for the generic drug valrubicin. It is possible that some of the dosage forms included below may not apply to the brand name Valstar.

For the Consumer

Applies to valrubicin: intravesical solution

As well as its needed effects, valrubicin (the active ingredient contained in Valstar) may cause unwanted side effects that require medical attention.

Minor Side Effects

Some valrubicin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Blood in urine
  • loss of bladder control
  • painful or difficult urination
  • red color in urine
  • strong urge to urinate
  • unusually frequent urination
Less common:
  • Increased urination at night
  • local burning sensation
  • Frequent urge to defecate
  • itching
  • loss of sense of taste

For Healthcare Professionals

Applies to valrubicin: irrigation solution


Local adverse reactions associated with valrubicin (the active ingredient contained in Valstar) usually occurred during or shortly after instillate and resolve within one to seven days after the instillation is removed from the bladder.[Ref]

Very common (10% or more): Any local bladder symptom (88%)
Common (1% to 10%): Procedure related local burning symptoms[Ref]


Very common (10% or more): Urinary frequency (61%), urinary urgency (57%), dysuria (56%), bladder spasm (31%), hematuria (29%), bladder pain (28%), urinary incontinence (22%), urinary tract infection (15%), cystitis (15%)
Common (1% to 10%): Nocturia, urinary retention, microscopic hematuria, urethral pain, pelvic pain, gross hematuria
Frequency not reported: Poor urine flow, urethritis[Ref]


The most common side effects were local bladder symptoms, including urinary frequency, urinary urgency, and dysuria.[Ref]


Common (1% to 10%): Abdominal pain, nausea, diarrhea, vomiting, flatulence
Frequency not reported: Tenesmus[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness
Frequency not reported: Taste loss[Ref]


Common (1% to 10%): Rash
Frequency not reported: Pruritus, local skin irritation[Ref]


Common (1% to 10%): Vasodilation[Ref]


Common (1% to 10%): Anemia[Ref]


Common (1% to 10%): Hyperglycemia, peripheral edema
Frequency not reported: Nonprotein nitrogen increased[Ref]


Common (1% to 10%): Back pain, myalgia[Ref]


Common (1% to 10%): Pneumonia[Ref]


Common (1% to 10%): Asthenia, malaise, chest pain, fever


1. "Product Information. Valstar (valrubicin)." Medeva Pharmaceuticals, Rochester, NY.

It is possible that some side effects of Valstar may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.