Generic Name: valrubicin (Intravesical route)
Medically reviewed by Drugs.com. Last updated on Feb 26, 2019.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Antineoplastic Agent
Chemical Class: Anthracycline
Uses for Valstar
Valrubicin is used as a solution that is run through a tube (instilled through a catheter) into the bladder to treat bladder cancer.
Valrubicin is to be administered only by or under the immediate supervision of your doctor.
Before using Valstar
Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of valrubicin in children with use in other age groups.
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing the use of valrubicin in the elderly with use in other age groups, this medicine has been used mostly in patients older than 60 years of age and is not expected to cause different side effects or problems in older people than it does in younger adults.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Interactions with food/tobacco/alcohol
Other medical problems
- Bladder irritation or other bladder problems—Increased risk of unwanted effects
- Small bladder—Possible trouble in being able to hold all of the solution
- Urinary tract infection
Proper use of Valstar
Your doctor may ask you to empty your bladder completely before the solution is instilled into it (unless a tube is used to drain the bladder).
Follow your doctor's instructions carefully about how long to hold the solution in your bladder:
- The solution should be held in your bladder for 2 hours. If you think you cannot hold it, tell your health care professional.
It is important that you drink extra fluids after each treatment with valrubicin so that you will pass more urine.
- For bladder instillation dosage form (solution):
- For bladder cancer:
- Adults—800 milligrams (mg) (75 milliliters [mL]) instilled into the bladder once a week for six weeks.
- For bladder cancer:
Precautions while using Valstar
Valrubicin commonly causes the urine to turn red for about 24 hours after it is given. This is normal and is no cause for concern. However, tell your doctor if you continue to pass red urine for longer than 24 hours.
Valstar side effects
- Blood in urine
- loss of bladder control
- painful or difficult urination
- red color in urine
- strong urge to urinate
- unusually frequent urination
- Increased urination at night
- local burning sensation
- Frequent urge to defecate
- loss of sense of taste
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