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Uvadex Side Effects

Generic Name: methoxsalen

Note: This document contains side effect information about methoxsalen. Some of the dosage forms listed on this page may not apply to the brand name Uvadex.

For the Consumer

Applies to methoxsalen: oral capsule, oral capsule liquid filled

Other dosage forms:

Along with its needed effects, methoxsalen (the active ingredient contained in Uvadex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking methoxsalen:

  • Blistering and peeling of skin
  • reddened, sore skin
  • swelling (especially of feet or lower legs)

Some side effects of methoxsalen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Less Common

Treatment with this medicine usually causes a slight reddening of your skin 24 to 48 hours after the treatment. This is an expected effect and is no cause for concern. However, check with your doctor right away if your skin becomes sore and red or blistered.

There is an increased risk of developing skin cancer after use of methoxsalen. You should check your body regularly and show your doctor any skin sores that do not heal, new skin growths, and skin growths that have changed in the way they look or feel.

Premature aging of the skin may occur as a result of prolonged methoxsalen therapy. This effect is permanent and is similar to what happens when a person sunbathes for long periods of time.

For Healthcare Professionals

Applies to methoxsalen: compounding powder, injectable solution, oral capsule

General

The most common adverse event was nausea, which may be minimized or avoided by taking the medication with milk or food, or dividing the dose into 2 portions taken approximately 30 minutes apart.[Ref]

Dermatologic

Very common (10% or more): Pruritus (10%)

Frequency not reported: Erythema, hypopigmentation, vesiculation and bullae formation, non-specific rash, herpes simplex, miliaria, urticaria, folliculitis, cutaneous tenderness, extension of psoriasis

Postmarketing reports: Rash[Ref]

-Pruritus can often be alleviated by frequent application of bland emollients or other topical agents.

-Severe pruritus may require systemic treatment. If pruritus is unresponsive to these measures, shield pruritic areas from further UVA exposure until it resolves.

-Discontinue treatment until pruritus resolution for intractable generalized pruritus.

Erythema:

-Mild, transient erythema at 24 to 48 hours after PUVA therapy is expected and indicates a therapeutic reaction.

-Any area showing moderate (grade 2 or higher) erythema should be shielded during subsequent UVA exposure until the erythema has resolved.

-Grade 2 or higher erythema that appears within 24 hours after treatment may signal a potentially severe burn.

-Erythema may progressively worsen over the next 24 hours, since peak erythemal reaction characteristically occurs 48 hours or later after methoxsalen ingestion.

-Monitor the patient closely and protect from further UVA and sunlight exposures.

Differences between PUVA erythema and sunburn or UVB phototherapy:

-The percent transmission through skin of UVS varies from 0 to 34%, where UVA varies from 1 to 80% (UVA is transmitted through a larger percentage of the skin)

-PUVA induced DNA lesions may lead to a DNA crosslink, which is more lethal and psoralen-DNA photoproducts may be unfamiliar substrates for DNA repair enzymes.

-DNA synthesis is suppressed longer after PUVA.

-The time course of delayed erythema with PUVA is different and may not involve the usual mediators seen in sunburn; PUVA-induced redness may be just beginning at 24 hours (UVB erythema is past its peak by this time).

-Histological alterations from PUVA show more dermal vessel damage and longer duration of epidermal and dermal abnormalities.[Ref]

Cardiovascular

Common (1% to 10%): Hypotension

Frequency not reported: Arrhythmia[Ref]

Gastrointestinal

Very common (10% or more): Nausea (10%)

Common (1% to 10%): Vomiting

Frequency not reported: Gastrointestinal disturbances

Postmarketing reports: Dysgeusia[Ref]

Immunologic

Common (1% to 10%): Infection/catheter related infection/ sepsis

Frequency not reported: Folliculitis[Ref]

Psychiatric

Frequency not reported: Nervousness, insomnia, depression[Ref]

Hypersensitivity

Postmarketing reports: Allergic reaction[Ref]

Local

Common (1% to 10%): Vascular access complication[Ref]

Other

Common (1% to 10%): Transient fever

Frequency not reported: Edema, malaise

Postmarketing reports: Pyrexia[Ref]

Nervous system

Frequency not reported: Dizziness, headache[Ref]

Musculoskeletal

Frequency not reported: Leg cramps[Ref]

References

1. "Product Information. Methoxsalen (methoxsalen)." Strides Pharma Inc., Lambertville, NJ.

2. "Product Information. Uvadex (methoxsalen)." Therakos Inc, Exton, PA.

3. "Product Information. Oxsoralen (methoxsalen)." ICN Pharmaceuticals Inc, Costa Mesa, CA.

4. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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