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Topicycline Side Effects

Generic Name: tetracycline topical

Note: This page contains side effects data for the generic drug tetracycline topical. It is possible that some of the dosage forms included below may not apply to the brand name Topicycline.

For the Consumer

Applies to tetracycline topical: topical application cream, topical application ointment, topical application solution

As well as its needed effects, tetracycline topical (the active ingredient contained in Topicycline) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking tetracycline topical, check with your doctor or nurse as soon as possible:

Less common:
  • Pain, redness, swelling, or other sign of irritation not present before use of this medicine

Minor Side Effects

Some tetracycline topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:For topical liquid form only
  • Dry or scaly skin
  • stinging or burning feeling
For cream and topical liquid forms only
  • Faint yellowing of the skin, especially around hair roots

For Healthcare Professionals

Applies to tetracycline topical: ophthalmic ointment, topical ointment, topical solution


Dermatitis has been reported rarely with topical application of tetracycline. One-third of patients may experience a stinging and burning sensation lasting no more than a few minutes. A faint yellowing of the skin has been reported, especially around the hair roots.[Ref]


Tetracycline topical (the active ingredient contained in Topicycline) is generally well tolerated. Side effects reported with systemic administered tetracycline such as gastrointestinal complaints, vaginitis, hematologic abnormalities, dental, and skeletal disorders have not been reported and are unlikely to occur with topical administration.[Ref]


1. "Product Information. Achromycin (tetracycline)." Lederle Laboratories, Wayne, NJ.

2. Fisher AA "Adverse reactions to topical clindamycin, erythromycin and tetracycline." Cutis 32 (1983): 415,419,424,428

It is possible that some side effects of Topicycline may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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