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Topicycline Side Effects

Generic name: tetracycline topical

Medically reviewed by Last updated on Apr 29, 2023.

Note: This document contains side effect information about tetracycline topical. Some dosage forms listed on this page may not apply to the brand name Topicycline.

Applies to tetracycline topical: topical application foam.

Serious side effects of Topicycline

Along with its needed effects, tetracycline topical (the active ingredient contained in Topicycline) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking tetracycline topical:

Less common

Other side effects of Topicycline

Some side effects of tetracycline topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For topical liquid form only

For cream and topical liquid forms only

For Healthcare Professionals

Applies to tetracycline topical: topical ointment, topical solution.


Dermatitis has been reported rarely with topical application of tetracycline. One-third of patients may experience a stinging and burning sensation lasting no more than a few minutes. A faint yellowing of the skin has been reported, especially around the hair roots.[Ref]


Tetracycline topical (the active ingredient contained in Topicycline) is generally well tolerated. Side effects reported with systemic administered tetracycline such as gastrointestinal complaints, vaginitis, hematologic abnormalities, dental, and skeletal disorders have not been reported and are unlikely to occur with topical administration.[Ref]


1. Product Information. Achromycin (tetracycline). Lederle Laboratories. 2001;PROD.

2. Fisher AA. Adverse reactions to topical clindamycin, erythromycin and tetracycline. Cutis. 1983;32:415,419,424,428.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.