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Topicycline Side Effects

Generic Name: tetracycline topical

Note: This document contains side effect information about tetracycline topical. Some of the dosage forms listed on this page may not apply to the brand name Topicycline.

For the Consumer

Applies to tetracycline topical: topical application cream, topical application ointment, topical application solution

Along with its needed effects, tetracycline topical (the active ingredient contained in Topicycline) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking tetracycline topical:

Less common
  • Pain, redness, swelling, or other sign of irritation not present before use of this medicine

Some side effects of tetracycline topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More commonFor topical liquid form only
  • Dry or scaly skin
  • stinging or burning feeling
For cream and topical liquid forms only
  • Faint yellowing of the skin, especially around hair roots

For Healthcare Professionals

Applies to tetracycline topical: ophthalmic ointment, topical ointment, topical solution


Dermatitis has been reported rarely with topical application of tetracycline. One-third of patients may experience a stinging and burning sensation lasting no more than a few minutes. A faint yellowing of the skin has been reported, especially around the hair roots.[Ref]


Tetracycline topical (the active ingredient contained in Topicycline) is generally well tolerated. Side effects reported with systemic administered tetracycline such as gastrointestinal complaints, vaginitis, hematologic abnormalities, dental, and skeletal disorders have not been reported and are unlikely to occur with topical administration.[Ref]


1. "Product Information. Achromycin (tetracycline)." Lederle Laboratories, Wayne, NJ.

2. Fisher AA "Adverse reactions to topical clindamycin, erythromycin and tetracycline." Cutis 32 (1983): 415,419,424,428

Some side effects of Topicycline may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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