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Tice BCG Vaccine Side Effects

Generic name: bcg

Medically reviewed by Last updated on Jun 28, 2024.

Note: This document contains side effect information about bcg. Some dosage forms listed on this page may not apply to the brand name Tice BCG Vaccine.

Applies to bcg: intravesical powder for suspension.


Intravesical route (Powder for Suspension; Powder for Solution)

Bacillus of Calmette and Guérin (BCG) infections have been reported in health care workers and in patients because of exposure to the vaccine during preparation and administration. Serious and fatal disseminated BCG infections have occurred with intravesical administration. Manifestations of disseminated infection may not develop for months or years after therapy as BCG may persist in the urinary tract for several months after treatment. TheraCys® and TICE® BCG contain live attenuated mycobacteria and because of the potential risk for transmission, they should be prepared, handled, and disposed of as a biohazard material.

Serious side effects of Tice BCG Vaccine

Along with its needed effects, bcg (the active ingredient contained in Tice BCG Vaccine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking bcg:

More common


Other side effects of Tice BCG Vaccine

Some side effects of bcg may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, Check with your doctor immediately if you notice the following side effects:

For Healthcare Professionals

Applies to bcg: intravesical powder for reconstitution, percutaneous powder for injection.


Very common (10% or more): Dysuria (60%), increased urgency/frequency (40%), drug induced cystitis (30%), bacterial cystitis (27%), hematuria (27%), pollakiuria

Common (1% to 10%): Urinary tract infection, urinary incontinence, micturition urgency, urine analysis abnormal, bladder cramps, hemorrhage cystitis, urinary retention

Uncommon (0.1% to 1%): Bladder constriction, pyuria, ureteric obstruction

Rare (0.01 to less than 0.1%): Epididymitis

Very rare (less than 0.01%): Orchitis, balanoposthitis, prostatitis, vulvovaginal discomfort[Ref]


Very common (10% or more): Malaise/fatigue/lethargy (19%), fever without infection (13%), influenza-like illness, pyrexia, rigors

Common (1% to 10%): Chills

Very rare (less than 0.01%): Reiter's syndrome, chest pain, peripheral edema, prostate specific antigen increased, weight decreased, BCG osteomyelitis[Ref]

Nervous system

Common (1% to 10%): Dizziness, vertigo

Very rare (less than 0.01%): Dysesthesia, hyperesthesia, paresthesia, somnolence, headache[Ref]


Common (1% to 10%): Anemia, leukopenia

Uncommon (0.1% to 1%): Pancytopenia, thrombocytopenia

Very rare (less than 0.01%): Lymphadenopathy

Frequency not reported: Axillary or cervical lymphadenopathy, regional suppurative lymphadenitis[Ref]


Common (1% to 10%): Abdominal pain, nausea, vomiting, diarrhea

Very rare (less than 0.01%): Dyspepsia, flatulence[Ref]


Common (1% to 10%): Infection

Uncommon (0.1% to 1%): Tuberculosis infections

Very rare (less than 0.01%): Disseminated BCG infection[Ref]


Common (1% to 10%): Skin rash, sweats

Uncommon (0.1% to 1%): Rashes, eruptions and exanthema not otherwise classified

Very rare (less than 0.01%): Lupus vulgaris, alopecia, hyperhidrosis, granuloma[Ref]


Common (1% to 10%): Pneumonitis

Rare (0.01% to 0.1%): Cough

Very rare (less than 0.01%): Pharyngitis, bronchitis, dyspnea, rhinitis[Ref]


Very rare (less than 0.01%): Renal failure acute[Ref]


Common (1% to 10%): Arthralgia, arthritis, myalgia

Very rare (less than 0.01%): Back pain[Ref]


Common (1% to 10%): Allergic symptoms[Ref]


Uncommon (0.1% to 1%): Hepatitis, hepatic enzyme increased[Ref]


Very rare (less than 0.01%): Hypotension[Ref]


Very rare (less than 0.01%): Confusional state[Ref]


Very rare (less than 0.01%): Anorexia[Ref]


Very rare (less than 0.01%): Conjunctivitis[Ref]


Frequency not reported: Injection site reactions: Induration, pustule formation, ulceration, caseous lesions, purulent draining, tenderness, itching, papules[Ref]

Frequently asked questions

More about Tice BCG Vaccine (bcg)

Patient resources

Other brands


Professional resources

Other formulations

Related treatment guides


1. "Product Information. Tice BCG Live (for intravesical use) (BCG)." Organon

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

4. "Product Information. BCG Vaccine (BCG vaccine)." Organon Pharmaceuticals

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.