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Teprotumumab Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jan 14, 2022.

For the Consumer

Applies to teprotumumab: intravenous powder for solution

Side effects requiring immediate medical attention

Along with its needed effects, teprotumumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking teprotumumab:

More common

  • Abdominal or stomach pain
  • blurred vision
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • increased hunger
  • increased thirst
  • increased urination
  • nausea
  • sweating
  • troubled breathing
  • unexplained weight loss
  • unusual tiredness or weakness
  • vomiting

Less common

Incidence not known

  • Bleeding from the rectum
  • diarrhea that may contain blood
  • severe stomach pain

Side effects not requiring immediate medical attention

Some side effects of teprotumumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Change or loss of hearing
  • change or loss of taste
  • dry skin
  • hair loss or thinning of the hair
  • mild diarrhea
  • muscle spasms
  • unusual tiredness or weakness

Incidence not known

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to teprotumumab: intravenous powder for injection


Very common (10% or more): Muscle spasms (25%)[Ref]


Very common (10% or more): Nausea (17%), diarrhea (12%)

Common (1% to 10%): Dysgeusia

Frequency not reported: Exacerbation of inflammatory bowel disease[Ref]


Very common (10% or more): Hyperglycemia (10%)[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]


Very common (10% or more): Alopecia (13%)

Common (1% to 10%): Dry skin[Ref]


Very common (10% or more): Fatigue (12%), hearing impairment (10%)

Common (1% to 10%): Infusion reactions (transient blood pressure increases, feeling hot, tachycardia, dyspnea, headache, and muscle pain)[Ref]


1. "Product Information. Tepezza (teprotumumab)." Horizon Therapeutics USA Inc (2020):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.