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Teprotumumab Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Sep 3, 2023.

Applies to teprotumumab: intravenous powder for solution.

Serious side effects of Teprotumumab

Along with its needed effects, teprotumumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking teprotumumab:

More common

Less common

Incidence not known

Other side effects of Teprotumumab

Some side effects of teprotumumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Incidence not known

For Healthcare Professionals

Applies to teprotumumab: intravenous powder for injection.


Very common (10% or more): Muscle spasms (25%)[Ref]


Very common (10% or more): Nausea (17%), diarrhea (12%)

Common (1% to 10%): Dysgeusia

Frequency not reported: Exacerbation of inflammatory bowel disease[Ref]


Very common (10% or more): Hyperglycemia (10%)[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]


Very common (10% or more): Alopecia (13%)

Common (1% to 10%): Dry skin[Ref]


Very common (10% or more): Fatigue (12%), hearing impairment (10%)

Common (1% to 10%): Infusion reactions (transient blood pressure increases, feeling hot, tachycardia, dyspnea, headache, and muscle pain)[Ref]


1. Product Information. Tepezza (teprotumumab). Horizon Therapeutics USA Inc. 2020.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.