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Tepezza Side Effects

Generic name: teprotumumab

Medically reviewed by Drugs.com. Last updated on Oct 25, 2020.

Note: This document contains side effect information about teprotumumab. Some of the dosage forms listed on this page may not apply to the brand name Tepezza.

For the Consumer

Applies to teprotumumab: intravenous solution reconstituted

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Change in hearing.
  • Infusion reactions have happened during or after the infusion. Tell your doctor right away if you have effects like fast heartbeat; feeling hot; shortness of breath; muscle pain; or signs of high blood pressure like headache, dizziness, passing out, or change in eyesight.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to teprotumumab: intravenous powder for injection

Musculoskeletal

Very common (10% or more): Muscle spasms (25%)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (17%), diarrhea (12%)

Common (1% to 10%): Dysgeusia

Frequency not reported: Exacerbation of inflammatory bowel disease[Ref]

Metabolic

Very common (10% or more): Hyperglycemia (10%)[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]

Dermatologic

Very common (10% or more): Alopecia (13%)

Common (1% to 10%): Dry skin[Ref]

Other

Very common (10% or more): Fatigue (12%), hearing impairment (10%)

Common (1% to 10%): Infusion reactions (transient blood pressure increases, feeling hot, tachycardia, dyspnea, headache, and muscle pain)[Ref]

References

1. "Product Information. Tepezza (teprotumumab)." Horizon Therapeutics USA Inc, Northbrook, IL.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.