Sklice Side Effects

Generic name: ivermectin topical

Medically reviewed by Drugs.com. Last updated on May 2, 2025.

Note: This document provides detailed information about Sklice Side Effects associated with ivermectin topical. Some dosage forms listed on this page may not apply specifically to the brand name Sklice.

Applies to ivermectin topical: topical application cream, topical application lotion.

Precautions

For patients using Sklice®:

• Head lice can easily spread from one person to another by direct contact with clothing, hats, bandannas, scarves, bedding, towels, washcloths, ribbons, hair bands, helmets, hairbrushes and combs, or hairs from infected persons. All members of your household should be checked for head lice and should receive treatment if they are found to be infected. If you have any questions about this, check with your doctor.
• To prevent the spread of lice: Dry-clean or wash your clothes, bedding, and personal items (including washcloths, towels, hats, scarves, combs, brushes, hairpieces, and wigs) in hot, soapy water. Tumble dry in a hot dryer for 20 minutes.
• Call your doctor right away if you have trouble breathing, eye irritation, skin or scalp irritation, or rash.
• Do not use this medicine for a hair or scalp problem that has not been checked by your doctor.
• Do not use this medicine to treat lice in the eyebrows or eyelashes. If you have lice in these areas, check with your doctor.

For patients using Soolantra®:

• If your skin problem does not improve within a few days or if it becomes worse, check with your doctor.
• Do not use this medicine for a skin problem that has not been checked by your doctor.
• If you have any questions about this, check with your doctor.

Common side effects of Sklice

Some side effects of ivermectin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Sklice

Along with its needed effects, ivermectin topical (the active ingredient contained in Sklice) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ivermectin topical:

For healthcare professionals

Applies to ivermectin topical: topical cream, topical lotion.

General adverse events

The most frequently reported side effects included skin burning sensation, skin irritation, pruritus, and dry skin, occurring in 1% or less of patients.^[Ref]

Dermatologic

• Common (1% to 10%): Burning sensation
• Uncommon (0.1% to 1%): Skin irritation, pruritus, dry skin
• Frequency not reported: Erythema, contact dermatitis, dandruff^[Ref]

Musculoskeletal

• Common (1% to 10%): Muscle strain, back pain^[Ref]

Nervous system

• Common (1% to 10%): Headache

Respiratory

• Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection, sinusitis^[Ref]

Immunologic

• Common (1% to 10%): Seasonal allergy^[Ref]

Ocular

• Frequency not reported: Conjunctivitis, ocular hyperemia, eye irritation^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection^[Ref]

See also:

Frequently asked questions

• How long does it take for Sklice (ivermectin) to kill head lice?
• How long does it take for Soolantra to start working?
• How often should I use Soolantra?
• Can you use Soolantra and metronidazole together?
• Does Soolantra Cream help with redness?

Further information

Sklice side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer