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Selsun Blue 2-in-1 Side Effects

Generic name: selenium sulfide topical

Medically reviewed by Last updated on Aug 6, 2022.

Note: This document contains side effect information about selenium sulfide topical. Some dosage forms listed on this page may not apply to the brand name Selsun Blue 2-in-1.

Applies to selenium sulfide topical: topical foam, topical lotion, topical shampoo.

Serious side effects of Selsun Blue 2-in-1

Along with its needed effects, selenium sulfide topical (the active ingredient contained in Selsun Blue 2-in-1) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking selenium sulfide topical:

Less common or rare

  • Skin irritation

Other side effects of Selsun Blue 2-in-1

Some side effects of selenium sulfide topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Unusual dryness or oiliness of hair or scalp

Less common

For Healthcare Professionals

Applies to selenium sulfide topical: compounding powder, topical foam, topical lotion, topical shampoo.


Dermatologic side effects including skin irritation, increased hair loss, and discoloration of hair have been reported.[Ref]

Discoloration of hair can be avoided or minimized by thoroughly rinsing hair after treatment.[Ref]

More about Selsun Blue 2-in-1 (selenium sulfide topical)

Patient resources

Other brands

Selsun Blue, SelRx, Dandrex, Selenos, ... +2 more

Professional resources

Other formulations

Related treatment guides


1. "Product Information. Selseb (selenium sulfide topical)." Doak Dermatologics Division (2005):

2. "Product Information. Selsun Blue Moisturizing Treatment (selenium sulfide topical)." Ross Product Division Pharmaceuticals (2005):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.