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Ruconest Side Effects

Generic Name: conestat alfa

Note: This page contains side effects data for the generic drug conestat alfa. It is possible that some of the dosage forms included below may not apply to the brand name Ruconest.

For the Consumer

Applies to conestat alfa: intravenous powder for injection

Get emergency medical help if you have signs of an allergic reaction: rash or hives; chest tightness, wheezing, difficult breathing; blue-colored lips or gums; fast heartbeats; feeling like you might pass out; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • sudden numbness or weakness (especially on one side of the body);

  • sudden severe headache, slurred speech, problems with vision or balance; or

  • pain, swelling, warmth, or redness in one or both legs.

Common side effects may include:

  • headache;

  • diarrhea; or

  • nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to conestat alfa: intravenous powder for injection


The most common adverse reactions were headache, nausea, and diarrhea.[Ref]

Nervous system

Very common (10% or more): Headache (up to 10%)
Common (1% to 10%): Vertigo, procedural headache
Uncommon (0.1% to 1%): Paresthesia[Ref]


Common (1% to 10%): Angioedema, erythema marginatum, skin burning sensation
Uncommon (0.1% to 1%): Urticaria
Postmarketing reports: Rash[Ref]


Common (1% to 10%): Nausea, diarrhea
Uncommon (0.1% to 1%): Abdominal discomfort, oral paresthesia
Postmarketing reports: Abdominal pain[Ref]


Common (1% to 10%): Sneezing
Uncommon (0.1% to 1%): Throat irritation[Ref]


Common (1% to 10%): Fibrin D-dimer increased[Ref]


Common (1% to 10%): C-reactive protein increased[Ref]


Common (1% to 10%): Back pain[Ref]


Common (1% to 10%): Lipoma


Uncommon (0.1% to 1%): Swelling[Ref]


1. "Product Information. Ruconest (conestat alfa)." Valeant Pharmaceuticals, Costa Mesa, CA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

It is possible that some side effects of Ruconest may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.