Generic Name: ecallantide (e KAL an tide)
Brand Names: Kalbitor
Medically reviewed on September 6, 2018
What is Kalbitor?
Kalbitor (ecallantide) is used to treat attacks of hereditary angioedema (an immune system disorder). This medication is used in people who are at least 12 years old.
Kalbitor is not a cure for hereditary angioedema.
Kalbitor may also be used for other purposes not listed in this medication guide.
You should not be treated with Kalbitor if you are allergic to ecallantide. Tell your doctor if you have a history of any type of allergy.
In an emergency situation it may not be possible to tell your caregivers about your health conditions. Make sure any doctor caring for you afterward knows you have received this medicine.
Before receiving this medicine
You should not be treated with Kalbitor if you are allergic to ecallantide.
If possible before you receive Kalbitor, tell your doctor if you have a history of any type of allergy.
It is not known whether Kalbitor will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether ecallantide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.
How is Kalbitor given?
Kalbitor is injected under the skin. A healthcare provider will give you this injection.
You will be watched closely after receiving your injection, to make sure you do not have an allergic reaction to the medication.
Kalbitor is usually given in 3 separate injections. If you still have symptoms of the angioedema attack, more injections may be given within 24 hours.
Kalbitor dosing information
Usual Adult Dose for Hereditary Angioedema:
30 mg subcutaneously in three 10 mg injections; may repeat an additional 30 mg within 24 hours if attack persists.
Usual Pediatric Dose for Hereditary Angioedema:
12 years and older: 30 mg subcutaneously in three 10 mg injections; may repeat an additional 30 mg within 24 hours if attack persists.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Because you will receive Kalbitor in a clinical setting, you are not likely to miss a dose.
What happens if I overdose?
Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid after receiving Kalbitor?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Kalbitor side effects
Tell your caregivers right away if you have any of these signs of an allergic reaction to Kalbitor within 1 hour after receiving your injection:
chest pain or tightness, fast or weak heartbeat;
wheezing, cough, throat irritation, trouble breathing;
hoarse voice, tight feeling in your throat, trouble swallowing;
swelling of your lips, tongue, or throat;
swelling or redness in your face;
itching, rash, or hives;
flushing (warmth, redness, or tingly feeling);
sneezing, runny or stuffy nose; or
dizziness, feeling like you might pass out.
An allergic reaction to ecallantide can cause symptoms that are similar to the signs of hereditary angioedema. Your caregivers will watch you closely to make sure you are not having an allergic reaction to ecallantide.
Common Kalbitor side effects may include:
stuffy nose, sore throat; or
skin reactions where the medicine was injected (redness, rash, itching, bruising, swelling).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Kalbitor?
Other drugs may interact with ecallantide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Kalbitor only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 2.01.
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