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Ecallantide

Generic Name: ecallantide (e KAL an tide)
Brand Name: Kalbitor

Medically reviewed by Drugs.com on Oct 22, 2018 – Written by Cerner Multum

What is ecallantide?

Ecallantide is used to treat attacks of hereditary angioedema (an immune system disorder). This medication is used in people who are at least 16 years old.

Ecallantide is not a cure for hereditary angioedema.

Ecallantide may also be used for other purposes not listed in this medication guide.

Important Information

You should not be treated with ecallantide if you are allergic to it. Tell your doctor if you have a history of any type of allergy.

In an emergency situation it may not be possible to tell your caregivers about your health conditions. Make sure any doctor caring for you afterward knows you have received ecallantide.

Before taking this medicine

You should not be treated with ecallantide if you are allergic to it.

If possible before you receive ecallantide, tell your doctor if you have a history of any type of allergy.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether ecallantide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.

How is ecallantide given?

Ecallantide is injected under the skin. A healthcare provider will give you this injection.

You will be watched closely after receiving ecallantide, to make sure you do not have an allergic reaction to the medication.

Ecallantide is usually given in 3 separate injections. If you still have symptoms of the angioedema attack, more injections may be given within 24 hours.

What happens if I miss a dose?

Because you will receive ecallantide in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since ecallantide is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving ecallantide?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Ecallantide side effects

Tell your caregivers right away if you have any of these signs of an allergic reaction within 1 hour after receiving ecallantide:

  • chest pain or tightness, fast or weak heartbeat;

  • wheezing, cough, throat irritation, trouble breathing;

  • hoarse voice, tight feeling in your throat, trouble swallowing;

  • swelling of your lips, tongue, or throat;

  • swelling or redness in your face;

  • itching, rash, or hives;

  • flushing (warmth, redness, or tingly feeling);

  • sneezing, runny or stuffy nose; or

  • dizziness, feeling like you might pass out.

An allergic reaction to ecallantide can cause symptoms that are similar to the signs of hereditary angioedema. Your caregivers will watch you closely to make sure you are not having an allergic reaction to ecallantide.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ecallantide dosing information

Usual Adult Dose for Hereditary Angioedema:

30 mg subcutaneously in three 10 mg injections; may repeat an additional 30 mg within 24 hours if attack persists.

Usual Pediatric Dose for Hereditary Angioedema:

12 years and older: 30 mg subcutaneously in three 10 mg injections; may repeat an additional 30 mg within 24 hours if attack persists.

What other drugs will affect ecallantide?

Other drugs may interact with ecallantide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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