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Ecallantide Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Sep 28, 2024.

Applies to ecallantide: subcutaneous solution.

Important warnings This medicine can cause some serious health issues

Subcutaneous route (solution)

Anaphylaxis has been reported after administration of ecallantide.

Because of this risk, ecallantide should only be administered by a healthcare professional who is aware of the similarity of symptoms between anaphylaxis and hereditary angioedema and who has the appropriate medical support to manage both conditions.

Patients should be monitored closely.

Common side effects of ecallantide

Some side effects of ecallantide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

Less common side effects

  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • muscle aches
  • nausea
  • sore throat

Serious side effects of ecallantide

Along with its needed effects, ecallantide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ecallantide:

Less common side effects

  • blurred vision
  • chest discomfort
  • confusion
  • cough
  • difficulty with breathing
  • difficulty with swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast heartbeat
  • feeling of warmth
  • fever
  • hives or welts, itching, or skin rash
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the face, neck, arms, and occasionally, upper chest
  • redness of the skin
  • runny nose
  • sneezing
  • stuffy nose
  • sweating
  • throat irritation
  • tightness in the chest
  • unusual tiredness or weakness

For healthcare professionals

Applies to ecallantide: subcutaneous solution.

General adverse events

The most common adverse reactions were headache, nausea, diarrhea, pyrexia, injection site reactions, and nasopharyngitis.[Ref]

Dermatologic

Gastrointestinal

Hypersensitivity

Local

Nervous system

Other

Respiratory

References

1. (2009) "Product Information. Kalbitor (ecallantide)." Dyax Corporation

Frequently asked questions

Further information

Ecallantide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.