Skip to Content

Conestat alfa Pregnancy and Breastfeeding Warnings

Conestat alfa is also known as: Ruconest

Conestat alfa Pregnancy Warnings

Use is recommended only if clearly needed and the benefit outweighs the risk. US FDA pregnancy category: B

One animal study revealed evidence of reproductive toxicity. There are no controlled data in human pregnancy. US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

See references

Conestat alfa Breastfeeding Warnings

The amount of C1 esterase inhibitor excreted into breast milk is expected to be small due to its large molecular weight. Any C1 esterase inhibitor present in breast milk is likely destroyed in the infant's gastrointestinal tract and not absorbed (neonates may be an exception).

UK: Use is not recommended unless benefit outweighs risk. US: Caution is recommended. Excreted into human milk: Unknown Excreted into animal milk: Data not available Comments: Human plasma-derived C1 esterase inhibitor is considered first-line by an international consensus panel for prophylaxis and treatment of maternal hereditary angioedema during lactation.

See references

References for pregnancy information

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  2. "Product Information. Ruconest (conestat alfa)." Valeant Pharmaceuticals, Costa Mesa, CA.

References for breastfeeding information

  1. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL:" ([cited 2013 -]):
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. "Product Information. Ruconest (conestat alfa)." Valeant Pharmaceuticals, Costa Mesa, CA.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.