Skip to Content

Rosadan Side Effects

Generic Name: metronidazole topical

Medically reviewed by Drugs.com. Last updated on Oct 7, 2020.

Note: This document contains side effect information about metronidazole topical. Some of the dosage forms listed on this page may not apply to the brand name Rosadan.

For the Consumer

Applies to metronidazole topical: topical cream, topical gel/jelly, topical lotion

Other dosage forms:

Side effects requiring immediate medical attention

Along with its needed effects, metronidazole topical (the active ingredient contained in Rosadan) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Side effects not requiring immediate medical attention

Some side effects of metronidazole topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Dry skin
  • redness or other signs of skin irritation not present before use of this medicine
  • stinging or burning of the skin
  • watering of eyes

Rare

  • Metallic taste in the mouth
  • nausea
  • tingling or numbness of arms, legs, hands, or feet

For Healthcare Professionals

Applies to metronidazole topical: topical cream, topical gel, topical kit, topical lotion, vaginal gel with applicator

Local

Very common (10% or more): Dryness (up to 28.5%), scaling (up to 24.6%), itching (up to 16.3%), pruritus (up to 15.8%), stinging (up to 11%), stinging/burning (up to 10.3%)

Common (1% to 10%): Burning, local allergic reaction

Frequency not reported: Condition aggravated (rosacea or acne), transient redness, irritation

Postmarketing reports: Application site reaction, local irritation[Ref]

Local cutaneous signs/symptoms of irritation that were worse than baseline included dryness (25.4% [mild: 17.1%; moderate: 7.7%; severe: 0.6%]), scaling (24.6% [mild: 16.2%; moderate: 7.9%; severe: 0.6%]), pruritus (15.8% [mild: 9.7%; moderate: 5%; severe: 1.1%]), and stinging/burning (10.3% [mild: 7.2%; moderate: 1.3%; severe: 1.8%]).[Ref]

Genitourinary

Very common (10% or more): Vaginal discharge (up to 12%)

Common (1% to 10%): Candida cervicitis/vaginitis, yeast infection, dysmenorrhea, metrorrhagia, vulvovaginal candidiasis, vulvovaginal pruritus, urinary tract infection (UTI), vaginal itching/irritation/burning/numbness, vulva/vaginal irritative symptoms, pelvic discomfort

Uncommon (0.1% to 1%): Vaginal mycosis, urine discoloration, UTI symptoms, vulva edema, menstrual discomfort/irregularities, vaginal spotting/bleeding

Frequency not reported: Breast enlargement, dysuria, female lactation, labial edema, menorrhagia, salpingitis, urinary frequency, vulvovaginal disorder, vulvovaginal discomfort, itching (vaginal and perianal), vulvar burning, vulvar lesions, uterine/menstrual/vaginal cramping, darkened urine

Postmarketing reports: Leukorrhea, vaginitis, vulvar disorder, genital pruritus

Oral or parenteral formulations:

-Frequency not reported: Yeast infection, darkened urine, vaginal discharge, vaginal itching, overgrowth of Candida in vagina, dyspareunia, proctitis, dysuria, cystitis, polyuria, incontinence, sense of pelvic pressure, vulva/vaginal irritative symptoms, itching (vaginal and perianal), vulvar burning, vulvar lesions, vaginal burning, pelvic discomfort, uterine/menstrual/vaginal cramping[Ref]

Other

Very common (10% or more): Fungal infection (up to 12%)

Common (1% to 10%): Infection, breast pain, unspecified cramping, abscess, accidental injury

Uncommon (0.1% to 1%): Fatigue

Frequency not reported: Mucous membrane disorder, pain, thirst, surgical/medical procedure

Postmarketing reports: Swelling face, facial edema, treatment failure (worsening of rosacea)

Oral or parenteral formulations:

-Frequency not reported: Fatigue, weakness[Ref]

Respiratory

Very common (10% or more): Influenza (up to 11%)

Common (1% to 10%): Pharyngitis, bronchitis, nasopharyngitis, sinusitis, rhinitis, upper respiratory tract infection, nasal congestion

Frequency not reported: Asthma[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, nausea, diarrhea/loose stools, gastritis, tooth disorder, gastrointestinal discomfort, abdominal cramps, vomiting, unpleasant taste/unusual feeling on tongue

Uncommon (0.1% to 1%): Constipation, dry mouth, abdominal bloating/noises

Frequency not reported: Dyspepsia, flatulence, gingivitis, abdominal cramping, abdominal bloating/gas

Postmarketing reports: Abdominal pain, diarrhea, nausea

Oral or parenteral formulations:

-Frequency not reported: Nausea, unpleasant taste/feeling on tongue, diarrhea, constipation, abdominal cramping, abdominal discomfort, vomiting, epigastric distress, "furry" tongue, glossitis, stomatitis, pancreatitis, gastrointestinal discomfort, gastrointestinal disturbance[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness, unpleasant taste, hypertonia

Uncommon (0.1% to 1%): Metallic taste, dysgeusia/unusual taste, paresthesia, hypoesthesia

Frequency not reported: Ataxia, drowsiness

Postmarketing reports: Peripheral neuropathy, taste perversion, dizziness, headache, paresthesia, metallic taste, tingling/numbness of extremities

Oral or parenteral formulations:

-Frequency not reported: Unpleasant taste, dizziness, headache, convulsive seizures, encephalopathy, aseptic meningitis, peripheral neuropathy (characterized mainly by numbness/paresthesia of an extremity), syncope, vertigo, incoordination, ataxia, confusion, dysarthria, unpleasant metallic taste, taste of alcoholic beverages modified[Ref]

Cardiovascular

Common (1% to 10%): Hypertension

Oral or parenteral formulations:

-Frequency not reported: Flattening of T-wave in ECG tracings[Ref]

Dermatologic

Common (1% to 10%): Pruritus, rash, contact dermatitis, dry skin, skin discomfort (burning, pain of skin/stinging), erythema/transient skin erythema, worsening of rosacea, skin irritation, psoriasis, seborrhea, skin infection, sunburn, urticaria

Frequency not reported: Acne, sweating, generalized itching/rash, severe flare of comedonal acne, rosacea aggravated

Postmarketing reports: Hyperpigmentation, pigmentation disorder, hypertrichosis, rash, urticaria, contact dermatitis, skin exfoliation, erythema, pruritus, burning, dryness, tightness, discomfort, rash, zoster lesion, pustules on the nose, vesicular bullous eruption

Oral or parenteral formulations:

-Frequency not reported: Urticaria, angioedema[Ref]

Metabolic

Common (1% to 10%): Decreased appetite

Frequency not reported: Anorexia, hypomagnesemia

Oral or parenteral formulations:

-Frequency not reported: Decreased appetite, anorexia[Ref]

Musculoskeletal

Common (1% to 10%): Bursitis, myalgia, osteoporosis

Uncommon (0.1% to 1%): Back pain, cramp[Ref]

Hematologic

Common (1% to 10%): Increased/decreased WBC counts

Oral or parenteral formulations:

-Frequency not reported: Reversible neutropenia, reversible thrombocytopenia

Ocular

Common (1% to 10%): Conjunctivitis

Frequency not reported: Eye irritation (watering/tearing)

Postmarketing reports: Eyelid edema, watery eyes

Oral or parenteral formulations:

-Frequency not reported: Optic neuropathy[Ref]

Oncologic

Common (1% to 10%): Skin carcinoma

Uncommon (0.1% to 1%): Basal cell carcinoma

Frequency not reported: Skin cancer[Ref]

Endocrine

Common (1% to 10%): Hypothyroidism

Hypersensitivity

Postmarketing reports: Allergic reaction

Oral or parenteral formulations:

-Frequency not reported: Allergic reaction, hypersensitivity reactions (including urticaria, erythematous rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, flushing, nasal congestion, dryness of mouth/vagina/vulva, fever, pruritus, fleeting joint pains), anaphylaxis

Psychiatric

Uncommon (0.1% to 1%): Depression, difficulty sleeping, irritability

Frequency not reported: Insomnia

Oral or parenteral formulations:

-Frequency not reported: Trouble sleeping, irritability, depression, insomnia, decreased libido[Ref]

Hepatic

Frequency not reported: Abnormal liver function test[Ref]

Renal

Frequency not reported: Pyelonephritis[Ref]

References

1. "Product Information. MetroNIDAZOLE Topical (metroNIDAZOLE topical)." G & W Laboratories Inc, South Plainfield, NJ.

2. "Product Information. Vandazole (metroNIDAZOLE topical)." Upsher-Smith Laboratories Inc, Minneapolis, MN.

3. "Product Information. MetroLotion (metroNIDAZOLE topical)." Galderma Laboratories Inc, Cranbury, NJ.

4. "Product Information. Metrogel (metronidazole)." Galderma Laboratories Inc, Fort Worth, TX.

5. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

6. Cerner Multum, Inc. "Australian Product Information." O 0

7. "Product Information. Rosadan (metroNIDAZOLE topical)." Medimetriks Pharmaceuticals Inc, Fairfield, NJ.

8. "Product Information. MetroNIDAZOLE Vaginal (metroNIDAZOLE topical)." Oceanside Pharmaceuticals, Bridgewater, NJ.

9. "Product Information. Noritate (metroNIDAZOLE topical)." sanofi-aventis, Bridgewater, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.