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Ripretinib Side Effects

Medically reviewed by Last updated on Sep 15, 2022.

Applies to ripretinib: oral tablet.

Serious side effects of Ripretinib

Along with its needed effects, ripretinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ripretinib:

More common

  • Blistering, peeling, loosening of the skin
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blurred vision
  • chest tightness
  • constipation
  • diarrhea
  • difficult or labored breathing
  • dizziness
  • headache
  • nausea or vomiting
  • nervousness
  • pounding in the ears
  • rash, redness, swelling, pain, or ulceration of the skin
  • scaling of the skin on the hands and feet
  • slow or fast heartbeat
  • stomach pain
  • tingling of the hands or feet
  • unusual weight gain or loss

Less common

  • Change in size, shape, or color of existing mole
  • chest pain or discomfort
  • decreased urine output
  • dilated neck veins
  • irregular breathing
  • irregular heartbeat
  • mole that leaks fluid or bleeds
  • new mole
  • pale skin
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness


  • Increased sensitivity of the skin to sunlight
  • redness or other discoloration of the skin
  • severe sunburn

Other side effects of Ripretinib

Some side effects of ripretinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty in moving
  • dry or itching skin
  • joint pain or swelling
  • lack or loss of strength
  • loss of appetite
  • loss or thinning of the hair
  • muscle pains or stiffness
  • swelling or inflammation of the mouth

For Healthcare Professionals

Applies to ripretinib: oral tablet.


Very common (10% or more): Neutropenia (42%), thrombocytopenia (40%), increased activated partial thromboplastin time anemia (24%), increased INR (21%), lymphopenia (13%), febrile neutropenia (11%), decreased neutrophil count (10%)[Ref]


Very common (10% or more): Myalgia (32%), arthralgia (18%), muscle spasms (15%)[Ref]


Very common (10% or more): Anorexia (27%), triglycerides increased (26%), phosphate decreased (26%), triglycerides increased (26%), calcium decreased (23%), weight loss (19%), weight loss (19%), sodium decreased (17%)[Ref]


Very common (10% or more): Blood bilirubin increased (21%), ALT increased (12%)[Ref]


Very common (10% or more): New primary cutaneous malignancies (e.g., cutaneous squamous cell carcinoma (cuSCC), keratoacanthoma, melanoma[Ref]


Very common (10% or more): Dyspnea (13%)[Ref]


Very common (10% or more): Fatigue (42%), CPK increased (21%), peripheral edema (17%), asthenia (13%)[Ref]

Nervous system

Very common (10% or more): Headache (19%)[Ref]


Very common (10% or more): Creatinine increased (16%)[Ref]


Very common (10% or more): Hypertension (14%)

Common (1% to 10%): Cardiac dysfunction (e.g., cardiac failure, acute left ventricular failure, diastolic dysfunction, ventricular hypertrophy)[Ref]


Very common (10% or more): Alopecia (52%), palmar-plantar erythrodysesthesia syndrome (PPES) (21%), dry skin (13%), pruritus (11%)[Ref]


Very common (10% or more): Nausea (39%), abdominal pain (36%), constipation (34%), lipase increased (32%), diarrhea (28%), vomiting (21%), serum amylase increased (13%), stomatitis (11%)[Ref]


1. "Product Information. Qinlock (ripretinib)." Deciphera Pharmaceuticals (2020):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.