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Quixin Side Effects

Generic Name: levofloxacin ophthalmic

Note: This page contains side effects data for the generic drug levofloxacin ophthalmic. It is possible that some of the dosage forms included below may not apply to the brand name Quixin.

For the Consumer

Applies to levofloxacin ophthalmic: ophthalmic solution

As well as its needed effects, levofloxacin ophthalmic (the active ingredient contained in Quixin) may cause unwanted side effects that require medical attention.

Minor Side Effects

Some levofloxacin ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • voice changes
  • body aches or pain
  • congestion
  • dryness or soreness of throat
  • runny nose
  • swelling of the eyelid
  • tender, swollen glands in neck
  • trouble in swallowing
  • Itching, pain, redness or swelling of eye or eyelid
  • watering of eyes
  • decreased vision
  • fever
  • feeling of having something in the eye
  • headache
  • hoarseness
  • eye burning, dryness, itching, or pain
  • increased sensitivity of eyes to light

For Healthcare Professionals

Applies to levofloxacin ophthalmic: ophthalmic solution


In general, side effects were mild or moderate, transient, and restricted to the eye. The most frequently reported adverse reactions with the 1.5% solution were headache and taste disturbances.[Ref]


Common (1% to 10%): Decreased/blurred vision, ocular infection, ocular pain/discomfort, ocular burning, mucous strand, photophobia
Uncommon (0.1% to 1%): Lid edema, ocular dryness, ocular itching, chemosis, corneal erosion, diplopia, floaters, lid erythema, lid matting, conjunctival papillary reactions, conjunctival injection, conjunctival follicles[Ref]


Common (1% to 10%): Instillation site irritation/discomfort[Ref]

Nervous system

Common (1% to 10%): Headache, taste disturbances[Ref]


Common (1% to 10%): Throat irritation, pharyngitis
Uncommon (0.1% to 1%): Rhinitis
Frequency not reported: Laryngeal edema[Ref]


Common (1% to 10%): Fever, infection, foreign body sensation[Ref]


Common (1% to 10%): Diarrhea, dyspepsia, nausea[Ref]


Uncommon (0.1% to 1%): Hyperemia[Ref]


Frequency not reported: Skin rash, contact eczema, contact irritation[Ref]

Contact eczema and irritation have been reported with the active component and/or the preservative, benzalkonium chloride.[Ref]


Uncommon (0.1% to 1%): Allergic reactions
Rare (0.01% to 0.1%): Extra-ocular allergic reactions (including skin rash)
Frequency not reported: Anaphylaxis[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Quixin (levofloxacin ophthalmic)" Santen Inc, Napa, CA.

It is possible that some side effects of Quixin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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