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Quixin Side Effects

Generic Name: levofloxacin ophthalmic

Note: This document contains side effect information about levofloxacin ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Quixin.

For the Consumer

Applies to levofloxacin ophthalmic: ophthalmic solution

Along with its needed effects, levofloxacin ophthalmic (the active ingredient contained in Quixin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects of levofloxacin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • voice changes
  • body aches or pain
  • congestion
  • dryness or soreness of throat
  • runny nose
  • swelling of the eyelid
  • tender, swollen glands in neck
  • trouble in swallowing
  • Itching, pain, redness or swelling of eye or eyelid
  • watering of eyes
  • decreased vision
  • fever
  • feeling of having something in the eye
  • headache
  • hoarseness
  • eye burning, dryness, itching, or pain
  • increased sensitivity of eyes to light

For Healthcare Professionals

Applies to levofloxacin ophthalmic: ophthalmic solution


In general, side effects were mild or moderate, transient, and restricted to the eye. The most frequently reported adverse reactions with the 1.5% solution were headache and taste disturbances.[Ref]


Common (1% to 10%): Decreased/blurred vision, ocular infection, ocular pain/discomfort, ocular burning, mucous strand, photophobia
Uncommon (0.1% to 1%): Lid edema, ocular dryness, ocular itching, chemosis, corneal erosion, diplopia, floaters, lid erythema, lid matting, conjunctival papillary reactions, conjunctival injection, conjunctival follicles[Ref]


Common (1% to 10%): Instillation site irritation/discomfort[Ref]

Nervous system

Common (1% to 10%): Headache, taste disturbances[Ref]


Common (1% to 10%): Throat irritation, pharyngitis
Uncommon (0.1% to 1%): Rhinitis
Frequency not reported: Laryngeal edema[Ref]


Common (1% to 10%): Fever, infection, foreign body sensation[Ref]


Common (1% to 10%): Diarrhea, dyspepsia, nausea[Ref]


Uncommon (0.1% to 1%): Hyperemia[Ref]


Frequency not reported: Skin rash, contact eczema, contact irritation[Ref]

Contact eczema and irritation have been reported with the active component and/or the preservative, benzalkonium chloride.[Ref]


Uncommon (0.1% to 1%): Allergic reactions
Rare (0.01% to 0.1%): Extra-ocular allergic reactions (including skin rash)
Frequency not reported: Anaphylaxis[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Quixin (levofloxacin ophthalmic)" Santen Inc, Napa, CA.

Some side effects of Quixin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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