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Pentolair Side Effects

Generic Name: cyclopentolate ophthalmic

Note: This document contains side effect information about cyclopentolate ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Pentolair.

For the Consumer

Applies to cyclopentolate ophthalmic: ophthalmic solution

Along with its needed effects, cyclopentolate ophthalmic (the active ingredient contained in Pentolair) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking cyclopentolate ophthalmic:

Symptoms of too much medicine being absorbed into the body
  • Clumsiness or unsteadiness
  • confusion
  • constipation, full feeling, passing gas, or stomach cramps or pain
  • fast or irregular heartbeat
  • convulsions (seizures)
  • fever
  • flushing or redness of face
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • passing urine less often
  • skin rash
  • slurred speech
  • swollen stomach (in infants)
  • thirst or dryness of mouth
  • unusual behavior, such as disorientation to time or place, failure to recognize people, hyperactivity, or restlessness, especially in children
  • unusual drowsiness, tiredness, or weakness

Some side effects of cyclopentolate ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

  • Blurred vision
  • burning of eye
  • eye irritation not present before therapy
  • increased sensitivity of eyes to light

For Healthcare Professionals

Applies to cyclopentolate ophthalmic: compounding powder, ophthalmic solution


Respiratory side effects have included decreased secretion in the pharynx, bronchi, and nasal passages.[Ref]


Cardiovascular side effects have included tachycardia and vasodilation.[Ref]


Dermatological side effects have included skin rash and decreased sweat gland secretion.[Ref]


Gastrointestinal side effects have included abdominal distention (in infants), diminished gastrointestinal motility, and decreased salivary secretion.[Ref]


General side effects have included hyperpyrexia.[Ref]


Genitourinary side effects have included urinary retention.[Ref]

Nervous system

Nervous system side effects have included ataxia, incoherent speech, restlessness, and seizures. Unusual drowsiness has also been reported.[Ref]


Ocular side effects have included increased intraocular pressure, burning, photophobia, blurred vision, irritation, hyperemia, conjunctivitis, blepharoconjunctivitis, punctate keratitis, and synechiae.[Ref]


Psychiatric side effects have included hallucinations, hyperactivity, disorientation as to time and place, and failure to recognize people.[Ref]


1. "Product Information. Cyclopentolate Hydrochloride (cyclopentolate ophthalmic)." Falcon Ophthalmics, Fort Worth, TX.

Some side effects of Pentolair may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.