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Optiray 350 Side Effects

Generic Name: ioversol

Note: This document contains side effect information about ioversol. Some of the dosage forms listed on this page may not apply to the brand name Optiray 350.

For the Consumer

Applies to ioversol: injection solution

Along with its needed effects, ioversol (the active ingredient contained in Optiray 350) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ioversol:

  • Arm, back, or jaw pain
  • blood in the stools or urine
  • blue lips and fingernails
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • bruising
  • changes in skin color
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • coughing
  • coughing or vomiting blood
  • coughing that sometimes produces a pink frothy sputum
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficult, fast, noisy breathing
  • difficulty in passing urine (dribbling)
  • difficulty with swallowing
  • dizziness or lightheadedness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • feeling of constant movement of self or surroundings
  • headache
  • hives or welts, itching, or skin rash
  • hoarseness
  • increased sweating
  • nausea
  • nervousness
  • painful urination
  • pains in the chest, groin, or legs, especially calves of the legs
  • pain, tenderness, or swelling of the foot or leg
  • pale skin
  • persistent bleeding or oozing from the puncture sites, mouth, or nose
  • pounding in the ears
  • rapid weight gain
  • redness of the skin
  • seizures
  • sensation of spinning
  • severe headaches of sudden onset
  • severe numbness, especially on one side of the face or body
  • severe, unusual tiredness or weakness
  • slow, fast, or irregular heartbeat
  • slow or irregular breathing
  • stupor
  • sudden loss of coordination
  • sudden onset of shortness of breath for no apparent reason
  • sudden onset of slurred speech
  • sudden vision changes
  • sweating
  • swelling around the eyes
  • swelling in the legs and ankles
  • unusual tiredness or weakness
Incidence not known
  • Agitation
  • blistering, peeling, or loosening of the skin
  • chills
  • coma
  • confusion
  • depression
  • diarrhea
  • extremely high fever or body temperature
  • fast, shallow breathing
  • fast, weak heartbeat
  • fever
  • hostility
  • irritability
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lethargy
  • muscle cramps
  • muscle twitching
  • no sensation in the legs
  • not able to pass urine
  • pale, clammy skin
  • red, irritated eyes
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
  • thirst
  • unable to move the legs

Some side effects of ioversol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare
  • Bad taste
  • collection of blood under the skin
  • deep, dark purple bruise
  • dry mouth
  • pain, redness, or pale skin at the injection site
  • ringing in the ears
  • vomiting

For Healthcare Professionals

Applies to ioversol: injectable solution


Adverse reactions following the use of this drug are generally independent of the dose and usually mild to moderate, of short duration and resolve spontaneously (without treatment).
The most frequently reported adverse reactions were mild discomfort, heat or cold sensation, pain during the injection, transient test perversion, nausea, vomiting, skin reactions such as and urticaria or erythema.[Ref]


Very common (10% or more): Feeling hot
Common (1% to 10%): Pain
Uncommon (0.1% to 1%): Vertigo, extravasation, shaking, chills, fever, feeling cold
Very rare (less than 0.01%): Tinnitus, edema, malaise, tiredness, sluggishness, feeling abnormal
Frequency not reported: Hyperthermia, pyrexia[Ref]


Common (1% to 10%): Nausea
Uncommon (0.1% to 1%): Vomiting, dry mouth
Very rare (less than 0.01%): Sialoadenitis, abdominal pain, tongue edema, dysphagia, hypersalivation
Frequency not reported: Diarrhea[Ref]

Nervous system

Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Cerebral infarct, lightheadedness, vasovagal reaction, disorientation, paresthesia, dysphasia, visual hallucinations, syncope, bad taste
Rare (0.01% to 0.1%): Dizziness, dysgeusia, tremor, convulsions, aphasia, paralysis, coma and death
Very rare (less than 0.01%): Loss of consciousness, speech disorder, somnolence, hypoesthesia, stupor
Frequency not reported: Dyskinesia, amnesia[Ref]


Uncommon (0.1% to 1%): Angina pectoris, hypotension, blood pressure fluctuation, arterial spasm, bradycardia, conduction defect, false aneurysm, hypertension, transient, arrhythmia, vascular trauma, hematoma
Rare (less than 0.1%): Arterial thrombosis, displacement of arterial plaques, venous thrombosis, dissection of the coronary vessels, transient sinus arrest, thrombophlebitis, flushing
Very rare (less than 0.01%): Heart block, abnormal ECG, atrial fibrillation, cerebrovascular disorder
Frequency not reported: Tachycardia; T-wave amplitude; ST depression, ST elevation; changes in cardiac output, left ventricular systolic and end-diastolic pressure, right ventricular systolic and pulmonary artery systolic pressure; decreases in systolic and diastolic blood pressure; myocardial infarction; angioneurotic edema, peripheral edema, vasodilation, thrombosis, disseminated intravascular coagulation, shock, cyanosis, extrasystole, palpitations, vasospasm[Ref]

Regardless of the contrast medium employed, the overall incidence of serious adverse reaction is higher with coronary arteriography than with other procedures. Cardiac decompensation, serious arrhythmias, myocardial ischemia, or myocardial infarction may occur during coronary arteriography and left ventriculography.[Ref]


Uncommon (0.1% to 1%): Urticaria, pruritus, facial edema, erythema
Rare (0.01% to 0.1%): Rash
Very rare (less than 0.01%): Angioedema, hyperhidrosis (including cold sweat)
Frequency not reported: Maculopapular rash, ecchymosis, tissue necrosis, toxic epidermal necrolysis, acute generalized erythematous pustulosis, erythema multiforme, pallor[Ref]


Uncommon (0.1% to 1%): Polyuria, urinary retention
Very rare (less than 0.01%): Incontinence, hematuria
Frequency not reported: Temporary anuria, dysuria[Ref]


Uncommon (0.1% to 1%): Blurred vision, periorbital edema
Very rare (less than 0.01%): Allergic conjunctivitis (including eye irritation, ocular hyperemia, watery eyes, swelling of conjunctiva, etc.)
Frequency not reported: Transient blindness[Ref]


Uncommon (0.1% to 1%): Laryngeal edema, pulmonary edema, sneezing, congestion, coughing, shortness of breath, hypoxia
Rare (0.01% to 0.1%): Laryngeal spasm and obstruction (including throat tightness, stridor, etc.), dyspnea, rhinitis, throat irritation
Very rare (less than 0.01%): Pharyngitis
Frequency not reported: Brachial plexus palsy following auxiliary artery injections, chest pain, choking, wheezing (may be an initial manifestation of more severe and infrequent reactions including asthmatic attack), bronchospasm, apnea, respiratory arrest, asthma, dysphonia[Ref]


Rare (0.01% to 0.1%): Anaphylaxis with loss of consciousness, coma, severe cardiovascular disturbances and death
Very rare (less than 0.01%): Anaphylactoid reactions[Ref]


Rare (less than 0.1%): Muscle spasm[Ref]


Very rare (less than 0.01%): injection site reactions (including pain, erythema, and hemorrhage up to necrosis especially after extravasation)
Frequency not reported: Hemorrhage or pseudoaneurysms at the puncture site[Ref]


Very rare (less than 0.01%): Agitation, anxiety, confusion[Ref]


Very rare (less than 0.01%): Acute renal failure, abnormal renal function, decreased creatinine clearance, increased BUN
Frequency not reported: Temporary nephropathy, renal colic[Ref]


Frequency not reported: Thyroid function tests indicative of hypothyroidism or transient thyroid suppression in adult and pediatric patients (including infants)[Ref]


Frequency not reported: Transient changes in hepatorenal chemistry tests[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Optiray 350 (ioversol)." Mallinckrodt Medical Inc, St. Louis, MO.

Some side effects of Optiray 350 may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.