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Ontak Side Effects

Generic name: denileukin diftitox

Medically reviewed by Drugs.com. Last updated on Jun 21, 2021.

Note: This document contains side effect information about denileukin diftitox. Some of the dosage forms listed on this page may not apply to the brand name Ontak.

For the Consumer

Applies to denileukin diftitox: parenteral injection concentrate

Warning

  • Administer only under supervision of qualified clinicians experienced in use of cytotoxic therapy.1

  • Closely monitor patients in a setting equipped and staffed by health-care personnel appropriately trained in CPR.1

Side effects include:

Hypoalbuminemia, chills/fever, asthenia, infection, chest pain, hypotension, vasodilation, edema, dyspnea, nausea/vomiting, anorexia, diarrhea, anemia, increase in serum aminotransferase concentrations, dizziness, pain, headache, cough, rash, pruritus.

Managing side effects (general information)

For Healthcare Professionals

Applies to denileukin diftitox: intravenous solution

Other

Very common (10% or more): Infusion reactions (up to 70.5%), pyrexia (up to 63.6%), rigors (up to 47.3%), fatigue (up to 46.7%), peripheral edema (up to 25.5%), asthenia (up to 18.2%), pain (up to 12.7%), chest pain (up to 12.7%)[Ref]

Cardiovascular

Very common (10% or more): Capillary leak syndrome (up to 32.5%), hypotension (up to 16.4%)[Ref]

Ocular

Common (1% to 10%): Visual changes (e.g., visual acuity loss)[Ref]

Dermatologic

Very common (10% or more): Rash (up to 24.4%), pruritus (up to 18.2%)[Ref]

Endocrine

Postmarketing reports: Thyroid conditions (hyperthyroidism, thyroiditis, thyrotoxicosis, and hypothyroidism)

Gastrointestinal

Very common (10% or more): Nausea (up to 60%), vomiting (up to 34.5%), diarrhea (up to 22.2%)[Ref]

Hepatic

Very common (10% or more): Increased ALT or increased AST (up to 84%)[Ref]

Metabolic

Very common (10% or more): Anorexia (up to 20%)[Ref]

Musculoskeletal

Very common (10% or more): Myalgia (up to 20%), back pain (up to 18.2%), arthralgia (up to 15.6%)[Ref]

Nervous system

Very common (10% or more): Headache (up to 28.9%), dizziness (up to 12.7%), dysgeusia (up to 10.9%)[Ref]

Respiratory

Very common (10% or more): Cough (up to 20%), upper respiratory tract infection (up to 13.3%), dyspnea (up to 13.3%)[Ref]

More about Ontak (denileukin diftitox)

Professional resources

Related treatment guides

References

1. "Product Information. Ontak (denileukin diftitox)." Ligand Pharmaceuticals, San Diego, CA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer