Ontak Side Effects
Generic Name: denileukin diftitox
Note: This document contains side effect information about denileukin diftitox. Some of the dosage forms listed on this page may not apply to the brand name Ontak.
For the Consumer
Applies to denileukin diftitox: parenteral injection concentrate
Side effects include:
Hypoalbuminemia, chills/fever, asthenia, infection, chest pain, hypotension, vasodilation, edema, dyspnea, nausea/vomiting, anorexia, diarrhea, anemia, increase in serum aminotransferase concentrations, dizziness, pain, headache, cough, rash, pruritus.
For Healthcare Professionals
Applies to denileukin diftitox: intravenous solution
Other
Very common (10% or more): Infusion reactions (up to 70.5%), pyrexia (up to 63.6%), rigors (up to 47.3%), fatigue (up to 46.7%), peripheral edema (up to 25.5%), asthenia (up to 18.2%), pain (up to 12.7%), chest pain (up to 12.7%)[Ref]
Cardiovascular
Very common (10% or more): Capillary leak syndrome (up to 32.5%), hypotension (up to 16.4%)[Ref]
Ocular
Common (1% to 10%): Visual changes (e.g., visual acuity loss)[Ref]
Dermatologic
Very common (10% or more): Rash (up to 24.4%), pruritus (up to 18.2%)[Ref]
Endocrine
Postmarketing reports: Thyroid conditions (hyperthyroidism, thyroiditis, thyrotoxicosis, and hypothyroidism)
Gastrointestinal
Very common (10% or more): Nausea (up to 60%), vomiting (up to 34.5%), diarrhea (up to 22.2%)[Ref]
Hepatic
Very common (10% or more): Increased ALT or increased AST (up to 84%)[Ref]
Metabolic
Very common (10% or more): Anorexia (up to 20%)[Ref]
Musculoskeletal
Very common (10% or more): Myalgia (up to 20%), back pain (up to 18.2%), arthralgia (up to 15.6%)[Ref]
Nervous system
Very common (10% or more): Headache (up to 28.9%), dizziness (up to 12.7%), dysgeusia (up to 10.9%)[Ref]
Respiratory
Very common (10% or more): Cough (up to 20%), upper respiratory tract infection (up to 13.3%), dyspnea (up to 13.3%)[Ref]
References
1. "Product Information. Ontak (denileukin diftitox)." Ligand Pharmaceuticals, San Diego, CA.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
